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Table 8 Final multivariate Cox analysis of breast cancer–free survival with six-biomarker definition of intrinsic subtypes a

From: Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index

Variable

HR

95% CI

P b

Tumor size, cm

 <2

1.0

  

 2 to 5

1.6

1.2 to 2.1

0.0003

 >5

2.0

1.2 to 3.2

0.005

Lymph nodes

 0

1.0

  

 1 to 3

1.4

1.0 to 1.8

0.01

 ≥4

2.8

2.1 to 3.7

<0.0001

Local therapy

 Mastectomy alone

1.0

  

 Mastectomy + RT

1.1

0.8 to 1.5

0.6

 Lumpectomy alone

1.2

0.7 to 2.1

0.5

 Lumpectomy + RT

0.6

0.5 to 0.8

0.0009

Hormonotherapy

 Yes

1.0

  

 No

0.7

0.5 to 0.9

0.01

Subtype

 Luminal A

1.0

  

 Luminal B

1.4

1.1 to 1.7

0.02

 Luminal HER2

1.4

0.8 to 2.2

0.2

 HER2-enriched

1.5

0.9 to 2.2

0.08

 Basal-like

1.2

0.8 to 1.8

0.3

 TNP nonbasal

1.6

0.9 to 2.6

0.06

  1. aCI, confidence interval; HR, hazard ratio; HER2, human epidermal growth factor receptor 2; RT, radiotherapy; TNP, triple-negative phenotype. bAll likelihood ratio, Wald and logrank statistical tests were two-sided.