Table 6 Final multivariate Cox analysis of breast cancer–free survival with four-biomarker definition of intrinsic subtypes a
Variables | HR | 95% CI | P b |
|---|---|---|---|
Tumor size, cm | |||
<2 | 1.0 | ||
2 to 5 | 1.6 | 1.2 to 2.1 | 0.0004 |
>5 | 1.9 | 1.2 to 3.1 | 0.005 |
Lymph nodes | |||
0 | 1.0 | ||
1 to 3 | 1.4 | 1.0 to 1.8 | 0.01 |
≥4 | 2.8 | 2.1 to 3.7 | <0.0001 |
Local therapy | |||
Mastectomy alone | 1.0 | ||
Mastectomy + RT | 1.1 | 0.7 to 1.5 | 0.6 |
Lumpectomy alone | 1.2 | 0.6 to 2.1 | 0.5 |
Lumpectomy + RT | 0.6 | 0.4 to 0.8 | 0.0005 |
Endocrine therapy | |||
Yes | 1.0 | ||
No | 0.7 | 0.5 to 0.9 | 0.01 |
Subtype | |||
Luminal A | 1.0 | ||
Luminal B | 1.3 | 1.0 to 1.7 | 0.02 |
HER2-enriched | 1.4 | 1.0 to 2.0 | 0.04 |
Triple-negative | 1.3 | 0.9 to 1.8 | 0.09 |