Skip to main content

Table 3 Risk of death of any cause or of breast cancer for adolescents and young adults (15 to 39 years of age) with breast cancer by tumor grade*, California, 2005-2009

From: Impact of breast cancer subtypes on 3-year survival among adolescent and young adult women

 

All-cause deaths

Breast cancer-specific deaths

Number of deaths

HR (95% CI)*

Number of deaths

HR (95% CI)*

Low tumor grade (I/II)

    

 Subtype†

    

  HR+/HER2-

44

1.00 (reference)

27

1.00 (reference)

  HR+/HER2+

19

1.57 (0.87-2.81)

16

2.23 (1.12-4.44)

  HR-/HER2+

9

1.52 (0.61-3.76)

7

2.37 (0.85-6.61)

  Triple negative

25

10.64 (5.66-20.00)

21

13.87 (6.49-29.64)

  Unclassified

16

1.34 (0.70-2.57)

13

2.05 (0.95-4.44)

High tumor grade (III)

    

 Subtype†

    

  HR+/HER2-

73

1.00 (reference)

67

1.00 (reference)

  HR+/HER2+

23

0.49 (0.29-0.81)

21

0.48 (0.28-0.81)

  HR-/HER2+

59

1.40 (0.95-2.06)

55

1.40 (0.93-2.10)

  Triple negative

162

2.24 (1.61-3.13)

140

2.14 (1.51-3.04)

  Unclassified

57

1.47 (0.98-2.21)

49

1.32 (0.85-2.05)

  1. * Cox models were adjusted for all variables presented in Table 2 and age at diagnosis (continuous), tumor size (continuous), and first course of treatment (chemotherapy (y/n), radiation (y/n), and surgery (y/n)); AJCC stage levels I-IV and unknown was included as a stratifying variable. P for interaction between breast cancer subtype and grade = 0.018 for all-cause mortality and =0.0735 for breast cancer-specific mortality.
  2. † Human epidermal growth factor receptor 2 (HER2), hormone receptor (HR), triple-negative (estrogen-receptor negative, progesterone-receptor negative, HER2-negative).