Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

Ma, Huiyan; Lu, Yani; Marchbanks, Polly A; Folger, Suzanne G; Strom, Brian L; McDonald, Jill A; Simon, Michael S; Weiss, Linda K; Malone, Kathleen E; Burkman, Ronald T; Sullivan-Halley, Jane; Deapen, Dennis M; Press, Michael F; Bernstein, Leslie

doi:10.1186/bcr3486

Table 4 Breast cancer-specific mortality associated with the ER/PR/HER2 score

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

ER/PR/HER2 score^a	Number of women	Number of deaths	Adjusted HR (95% CI)
ER/PR/HER2 score^a	Number of women	Number of deaths	Model 1^b	Model 2^c
Women with ER-negative invasive breast cancer
Overall
< 0	60	15	Referent	Referent
0	337	103	1.32 (0.76 to 2.32)	1.30 (0.74 to 2.28)
> 0	109	39	1.43 (0.77 to 2.69)	1.43 (0.76 to 2.67)
Trend			P_trend = 0.30	P_trend = 0.29
White women
< 0	35	9	Referent	Referent
0	162	46	1.20 (0.55 to 2.62)	1.09 (0.48 to 2.45)
> 0	54	14	1.16 (0.46 to 2.90)	1.09 (0.43 to 2.76)
Trend			P_trend = 0.79	P_trend = 0.88
Black women
< 0	25	6	Referent	Referent
0	175	57	1.46 (0.59 to 3.61)	1.47 (0.60 to 3.64)
> 0	55	25	1.57 (0.61 to 4.06)	1.55 (0.60 to 4.03)
Trend			P_trend = 0.42	P_trend = 0.45
Homogeneity of trends between white women and black women			P_homogeneity = 0.36	P_homogeneity = 0.32
Women with ER-positive invasive breast cancer
Quartiles of ER/PR/HER2 score^d
Overall
Q1	175	18	Referent	Referent
Q2	177	22	1.27 (0.65 to 2.45)	1.39 (0.71 to 2.70)
Q3	172	33	2.04 (1.10 to 3.81)	2.00 (1.07 to 3.76)
Q4	174	42	2.71 (1.48 to 4.95)	2.48 (1.36 to 4.55)
Trend			P_trend = 0.0002	P_trend = 0.001
White women
Q1	118	9	Referent	Referent
Q2	105	10	1.41 (0.53 to 3.74)	1.37 (0.52 to 3.62)
Q3	113	20	2.03 (0.84 to 4.92)	1.98 (0.82 to 4.78)
Q4	94	23	2.77 (1.19 to 6.45)	2.62 (1.12 to 6.11)
Trend			P_trend = 0.01	P_trend = 0.01
Black women
Q1	57	9	Referent	Referent
Q2	72	12	1.32 (0.50 to 3.51)	1.60 (0.58 to 4.45)
Q3	59	13	2.34 (0.85 to 6.42)	2.34 (0.83 to 6.55)
Q4	80	19	3.43 (1.33 to 8.84)	2.88 (1.08 to 7.67)
Trend			P_trend = 0.006	P_trend = 0.03
Homogeneity of trends between white women and black women			P_homogeneity = 0.56	P_homogeneity = 0.32

CI, confidence interval; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; HR, hazard ratio; PR, progesterone receptor.
^aER/PR/HER2 score = 94.7 × (–0.100 ER₁₀ – 0.079 PR₁₀ + 0.586 HER2); the range of ER/PR/HER2 scores was –71.07 to 55.49 in women with ER-negative tumor and –141.10 to 53.92 in women with ER-positive tumor.
^bMultivariable Cox proportional hazards regression models using age (in days) as the time metric stratified by age (in years) and adjusted for race (white, black), study site (Detroit, Los Angeles), tumor stage (localized, non-localized).
^cAdditionally adjusted for histologic grade (low, intermediate, high); low and intermediate were combined into a single category in analyses for women with ER-negative tumors due to a small number of women with a low grade.
^dQuartiles of ER/PR/HER2 scores in all women with ER-positive tumors were Q1 (–141.10 to –97.33), Q2 (–97.32 to –68.98), Q3 (–68.97 to –36.66), and Q4 (–36.65 to 53.92).

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ISSN: 1465-542X

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