Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

Ma, Huiyan; Lu, Yani; Marchbanks, Polly A; Folger, Suzanne G; Strom, Brian L; McDonald, Jill A; Simon, Michael S; Weiss, Linda K; Malone, Kathleen E; Burkman, Ronald T; Sullivan-Halley, Jane; Deapen, Dennis M; Press, Michael F; Bernstein, Leslie

doi:10.1186/bcr3486

Table 3 Breast cancer-specific mortality associated with the estrogen receptor Histo-score

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

ER H-score^a	Number of women	Number of deaths	Adjusted HR (95% CI)
ER H-score^a	Number of women	Number of deaths	Model 1^b	Model 2^c
Overall
<1 (ER-negative)	506	157	Referent	Referent
1 to 50	173	34	0.70 (0.48 to 1.03)	0.81 (0.54 to 1.21)
51 to 100	173	31	0.58 (0.39 to 0.87)	0.68 (0.45 to 1.03)
101 to 150	226	33	0.45 (0.31 to 0.67)	0.53 (0.35 to 0.81)
151 to 225	126	17	0.39 (0.23 to 0.65)	0.48 (0.28 to 0.84)
Trend			P_trend <0.0001	P_trend = 0.0004
Trend in women with ER-positive tumors only			P_trend = 0.008	P_trend = 0.02
Per 20 unit increase			0.90 (0.86 to 0.94)	0.92 (0.88 to 0.97)
Per 20 unit increase in women with ER-positive tumors only			0.90 (0.83 to 0.98)	0.90 (0.84 to 0.99)
White women
<1 (ER-negative)	251	69	Referent	Referent
1 to 50	107	22	0.66 (0.39 to 1.11)	0.85 (0.48 to 1.52)
51 to 100	104	17	0.46 (0.26 to 0.82)	0.59 (0.32 to 1.09)
101 to 150	141	18	0.34 (0.19 to 0.58)	0.45 (0.24 to 0.83)
151 to 225	78	5	0.20 (0.08 to 0.52)	0.29 (0.11 to 0.76)
Trend			P_trend <0.0001	P_trend = 0.0006
Trend in women with ER-positive tumors only			P_trend = 0.008	P_trend = 0.01
Per 20 unit increase			0.69 (0.59 to 0.79)	0.75 (0.64 to 0.88)
Per 20 unit increase in women with ER-positive tumors only			0.66 (0.49 to 0.90)	0.68 (0.50 to 0.92)
Black women
<1 (ER-negative)	255	88	Referent	Referent
1 to 50	66	12	0.51 (0.27 to 0.94)	0.56 (0.30 to 1.06)
51 to 100	69	14	0.66 (0.36 to 1.19)	0.72 (0.39 to 1.35)
101 to 150	85	15	0.55 (0.31 to 0.99)	0.61 (0.33 to 1.11)
151 to 225	48	12	0.54 (0.28 to 1.05)	0.64 (0.32 to 1.28)
Trend			P_trend = 0.008	P_trend = 0.07
Trend in women with ER-positive tumors only			P_trend = 0.41	P_trend = 0.59
Per 20 unit increase			0.93 (0.88 to 0.98)	0.95 (0.89 to 1.01)
Per 20 unit increase in women with ER-positive tumors only			0.96 (0.85 to 1.09)	0.97 (0.86 to 1.10)
Homogeneity between white women and black women
Trend			P_homogeneity = 0.10	P_homogeneity = 0.09
Trend in women with ER-positive tumors only			P_homogeneity = 0.05	P_homogeneity = 0.02
Per 20 unit increase			P_homogeneity = 0.08	P_homogeneity = 0.08
Per 20 unit increase in women with ER-positive tumors only			P_homogeneity = 0.05	P_homogeneity = 0.02

CI, confidence interval; ER, estrogen receptor; HR, hazard ratio.
^aER Histo-score = (% of cells stained at weak intensity category × 1) + (% of cells stained at intermediate intensity category × 2) + (% of cells stained at strong intensity category × 3).
^bMultivariable Cox proportional hazards regression models using age (in days) as the time metric stratified by age (in years) and adjusted for race (white, black), study site (Detroit, Los Angeles), tumor stage (localized, non-localized).
^cAdditionally adjusted for histologic grade (low, intermediate, high).

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ISSN: 1465-542X

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