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Table 3 Breast cancer-specific mortality associated with the estrogen receptor Histo-score

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

ER H-scorea Number of women Number of deaths Adjusted HR (95% CI)
Model 1b Model 2c
Overall     
<1 (ER-negative) 506 157 Referent Referent
1 to 50 173 34 0.70 (0.48 to 1.03) 0.81 (0.54 to 1.21)
51 to 100 173 31 0.58 (0.39 to 0.87) 0.68 (0.45 to 1.03)
101 to 150 226 33 0.45 (0.31 to 0.67) 0.53 (0.35 to 0.81)
151 to 225 126 17 0.39 (0.23 to 0.65) 0.48 (0.28 to 0.84)
Trend    Ptrend <0.0001 Ptrend = 0.0004
Trend in women with ER-positive tumors only    Ptrend = 0.008 Ptrend = 0.02
Per 20 unit increase    0.90 (0.86 to 0.94) 0.92 (0.88 to 0.97)
Per 20 unit increase in women with ER-positive tumors only    0.90 (0.83 to 0.98) 0.90 (0.84 to 0.99)
White women     
<1 (ER-negative) 251 69 Referent Referent
1 to 50 107 22 0.66 (0.39 to 1.11) 0.85 (0.48 to 1.52)
51 to 100 104 17 0.46 (0.26 to 0.82) 0.59 (0.32 to 1.09)
101 to 150 141 18 0.34 (0.19 to 0.58) 0.45 (0.24 to 0.83)
151 to 225 78 5 0.20 (0.08 to 0.52) 0.29 (0.11 to 0.76)
Trend    Ptrend <0.0001 Ptrend = 0.0006
Trend in women with ER-positive tumors only    Ptrend = 0.008 Ptrend = 0.01
Per 20 unit increase    0.69 (0.59 to 0.79) 0.75 (0.64 to 0.88)
Per 20 unit increase in women with ER-positive tumors only    0.66 (0.49 to 0.90) 0.68 (0.50 to 0.92)
Black women     
<1 (ER-negative) 255 88 Referent Referent
1 to 50 66 12 0.51 (0.27 to 0.94) 0.56 (0.30 to 1.06)
51 to 100 69 14 0.66 (0.36 to 1.19) 0.72 (0.39 to 1.35)
101 to 150 85 15 0.55 (0.31 to 0.99) 0.61 (0.33 to 1.11)
151 to 225 48 12 0.54 (0.28 to 1.05) 0.64 (0.32 to 1.28)
Trend    Ptrend = 0.008 Ptrend = 0.07
Trend in women with ER-positive tumors only    Ptrend = 0.41 Ptrend = 0.59
Per 20 unit increase    0.93 (0.88 to 0.98) 0.95 (0.89 to 1.01)
Per 20 unit increase in women with ER-positive tumors only    0.96 (0.85 to 1.09) 0.97 (0.86 to 1.10)
Homogeneity between white women and black women    
Trend    Phomogeneity = 0.10 Phomogeneity = 0.09
Trend in women with ER-positive tumors only    Phomogeneity = 0.05 Phomogeneity = 0.02
Per 20 unit increase    Phomogeneity = 0.08 Phomogeneity = 0.08
Per 20 unit increase in women with ER-positive tumors only    Phomogeneity = 0.05 Phomogeneity = 0.02
  1. CI, confidence interval; ER, estrogen receptor; HR, hazard ratio.
  2. aER Histo-score = (% of cells stained at weak intensity category × 1) + (% of cells stained at intermediate intensity category × 2) + (% of cells stained at strong intensity category × 3).
  3. bMultivariable Cox proportional hazards regression models using age (in days) as the time metric stratified by age (in years) and adjusted for race (white, black), study site (Detroit, Los Angeles), tumor stage (localized, non-localized).
  4. cAdditionally adjusted for histologic grade (low, intermediate, high).