Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

Ma, Huiyan; Lu, Yani; Marchbanks, Polly A; Folger, Suzanne G; Strom, Brian L; McDonald, Jill A; Simon, Michael S; Weiss, Linda K; Malone, Kathleen E; Burkman, Ronald T; Sullivan-Halley, Jane; Deapen, Dennis M; Press, Michael F; Bernstein, Leslie

doi:10.1186/bcr3486

Table 2 Breast cancer-specific mortality associated with percentage of tumor cell nuclei positively stained for estrogen receptor

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

% of cells staining	Number of women	Number of deaths	Adjusted HR (95% CI)
% of cells staining	Number of women	Number of deaths	Model 1^a	Model 2^b
Overall
<1 (ER-negative)	506	157	Referent	Referent
≥1 (ER-positive)	698	115	0.53 (0.41 to 0.68)	0.64 (0.48 to 0.85)
1 to 39	117	27	0.81 (0.53 to 1.24)	0.93 (0.60 to 1.43)
40 to 59	118	18	0.55 (0.34 to 0.91)	0.66 (0.39 to 1.12)
60 to 79	193	31	0.50 (0.33 to 0.74)	0.57 (0.38 to 0.88)
80 to 100	270	39	0.43 (0.30 to 0.62)	0.52 (0.35 to 0.78)
Trend			P_trend <0.0001	P_trend = 0.0003
Trend in women with ER-positive tumors only			P_trend = 0.004	P_trend = 0.006
Per 10% increase			0.92 (0.89 to 0.95)	0.94 (0.91 to 0.97)
Per 10% increase in women with ER-positive tumors only			0.91 (0.84 to 0.99)	0.91 (0.84 to 0.99)
White women
<1 (ER-negative)	251	69	Referent	Referent
≥1 (ER-positive)	430	62	0.42 (0.29 to 0.61)	0.56 (0.36 to 0.87)
1 to 39	75	18	0.81 (0.46 to 1.43)	1.04 (0.57 to 1.91)
40 to 59	66	10	0.46 (0.22 to 0.94)	0.65 (0.30 to 1.43)
60 to 79	123	17	0.37 (0.21 to 0.66)	0.47 (0.25 to 0.86)
80 to 100	166	17	0.28 (0.16 to 0.50)	0.39 (0.21 to 0.73)
Trend			P_trend <0.0001	P_trend = 0.0004
Trend in women with ER-positive tumors only			P_trend = 0.001	P_trend = 0.002
Per 10% increase			0.88 (0.84 to 0.93)	0.91 (0.86 to 0.96)
Per 10% increase in women with ER-positive tumors only			0.85 (0.76 to 0.96)	0.86 (0.76 to 0.96)
Black women
<1 (ER-negative)	255	88	Referent	Referent
≥1 (ER-positive)	268	53	0.56 (0.39 to 0.81)	0.62 (0.42 to 0.94)
1 to 39	42	9	0.56 (0.28 to 1.15)	0.63 (0.30 to 1.29)
40 to 59	52	8	0.50 (0.24 to 1.06)	0.55 (0.25 to 1.21)
60 to 79	70	14	0.60 (0.33 to 1.08)	0.65 (0.35 to 1.21)
80 to 100	104	22	0.56 (0.34 to 0.93)	0.64 (0.37 to 1.10)
Trend			P_trend = 0.007	P_trend = 0.06
Trend in women with ER-positive tumors only			P_trend = 0.54	P_trend = 0.67
Per 10% increase			0.94 (0.90 to 0.98)	0.95 (0.91 to 1.00)
Per 10% increase in women with ER-positive tumors only			0.98 (0.85 to 1.12)	1.00 (0.87 to 1.14)
Homogeneity between white women and black women
ER-positive versus ER-negative			P_homogeneity = 0.56	P_homogeneity = 0.55
Trend			P_homogeneity = 0.13	P_homogeneity = 0.12
Trend in women with ER-positive tumors only			P_homogeneity = 0.05	P_homogeneity = 0.02
Per 10% increase			P_homogeneity = 0.16	P_homogeneity = 0.15
Per 10% increase in women with ER-positive tumors only			P_homogeneity = 0.06	P_homogeneity = 0.02

CI, confidence interval; ER, estrogen receptor; HR, hazard ratio.
^aMultivariable Cox proportional hazards regression models using age (in days) as the time metric stratified by age (in years) and adjusted for race (white, black), study site (Detroit, Los Angeles), tumor stage (localized, non-localized).
^bAdditionally adjusted for histologic grade (low, intermediate, high).

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