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Table 2 Breast cancer-specific mortality associated with percentage of tumor cell nuclei positively stained for estrogen receptor

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

% of cells staining Number of women Number of deaths Adjusted HR (95% CI)
Model 1a Model 2b
Overall     
<1 (ER-negative) 506 157 Referent Referent
≥1 (ER-positive) 698 115 0.53 (0.41 to 0.68) 0.64 (0.48 to 0.85)
1 to 39 117 27 0.81 (0.53 to 1.24) 0.93 (0.60 to 1.43)
40 to 59 118 18 0.55 (0.34 to 0.91) 0.66 (0.39 to 1.12)
60 to 79 193 31 0.50 (0.33 to 0.74) 0.57 (0.38 to 0.88)
80 to 100 270 39 0.43 (0.30 to 0.62) 0.52 (0.35 to 0.78)
Trend    Ptrend <0.0001 Ptrend = 0.0003
Trend in women with ER-positive tumors only    Ptrend = 0.004 Ptrend = 0.006
Per 10% increase    0.92 (0.89 to 0.95) 0.94 (0.91 to 0.97)
Per 10% increase in women with ER-positive tumors only    0.91 (0.84 to 0.99) 0.91 (0.84 to 0.99)
White women     
<1 (ER-negative) 251 69 Referent Referent
≥1 (ER-positive) 430 62 0.42 (0.29 to 0.61) 0.56 (0.36 to 0.87)
1 to 39 75 18 0.81 (0.46 to 1.43) 1.04 (0.57 to 1.91)
40 to 59 66 10 0.46 (0.22 to 0.94) 0.65 (0.30 to 1.43)
60 to 79 123 17 0.37 (0.21 to 0.66) 0.47 (0.25 to 0.86)
80 to 100 166 17 0.28 (0.16 to 0.50) 0.39 (0.21 to 0.73)
Trend    Ptrend <0.0001 Ptrend = 0.0004
Trend in women with ER-positive tumors only    Ptrend = 0.001 Ptrend = 0.002
Per 10% increase    0.88 (0.84 to 0.93) 0.91 (0.86 to 0.96)
Per 10% increase in women with ER-positive tumors only    0.85 (0.76 to 0.96) 0.86 (0.76 to 0.96)
Black women     
<1 (ER-negative) 255 88 Referent Referent
≥1 (ER-positive) 268 53 0.56 (0.39 to 0.81) 0.62 (0.42 to 0.94)
1 to 39 42 9 0.56 (0.28 to 1.15) 0.63 (0.30 to 1.29)
40 to 59 52 8 0.50 (0.24 to 1.06) 0.55 (0.25 to 1.21)
60 to 79 70 14 0.60 (0.33 to 1.08) 0.65 (0.35 to 1.21)
80 to 100 104 22 0.56 (0.34 to 0.93) 0.64 (0.37 to 1.10)
Trend    Ptrend = 0.007 Ptrend = 0.06
Trend in women with ER-positive tumors only    Ptrend = 0.54 Ptrend = 0.67
Per 10% increase    0.94 (0.90 to 0.98) 0.95 (0.91 to 1.00)
Per 10% increase in women with ER-positive tumors only    0.98 (0.85 to 1.12) 1.00 (0.87 to 1.14)
Homogeneity between white women and black women
ER-positive versus ER-negative    Phomogeneity = 0.56 Phomogeneity = 0.55
Trend    Phomogeneity = 0.13 Phomogeneity = 0.12
Trend in women with ER-positive tumors only    Phomogeneity = 0.05 Phomogeneity = 0.02
Per 10% increase    Phomogeneity = 0.16 Phomogeneity = 0.15
Per 10% increase in women with ER-positive tumors only    Phomogeneity = 0.06 Phomogeneity = 0.02
  1. CI, confidence interval; ER, estrogen receptor; HR, hazard ratio.
  2. aMultivariable Cox proportional hazards regression models using age (in days) as the time metric stratified by age (in years) and adjusted for race (white, black), study site (Detroit, Los Angeles), tumor stage (localized, non-localized).
  3. bAdditionally adjusted for histologic grade (low, intermediate, high).