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Table 1 Descriptive statistics for the measures of estrogen receptor expression by follow-up outcome

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

 

Overall

Follow-up outcome

Died from breast cancer

Died from other causes

Alive at the end of follow-up

P F-test

Overall

n = 1,204

n = 272

n = 63

n = 869

 

ER-positivea (%)

58.0

42.5b

67.0b

61.8b

 

Among women with ER-positivea tumor

     

  % of tumor cell nuclei positively stained for ER

64.7 (25.5)

62.2 (27.0)

65.6 (24.5)

65.1 (25.2)

0.53

  ER H-scorec

100.8 (53.0)

93.0 (52.9)

104.5 (54.6)

102.2 (52.9)

0.22

  ER/PR/HER2 scored

–64.8 (40.6)

–49.9 (43.5)

–65.7 (34.7)

–67.9 (39.8)

<0.0001

White women

n = 681

n = 131

n = 24

n = 526

 

ER-positivea (%)

62.5b

47.2b

78.6b

65.8b

 

Among women with ER-positivea tumor

     

  % of tumor cell nuclei positively stained for ER

64.6 (25.9)

58.0 (27.4)

74.4 (18.1)

65.2 (25.7)

0.03

  ER H-scorec

100.7 (53.2)

82.3 (48.8)

122.1 (44.9)

102.8 (53.7)

0.004

  ER/PR/HER2 scored

–67.6 (39.7)

–46.1 (44.7)

–78.8 (26.3)

–70.8 (38.2)

<0.0001

Black women

n = 523

n = 141

n = 39

n = 343

 

ER-positivea (%)

51.3b

38.0b

60.0b

55.8b

 

Among women with ER-positivea tumor

     

  % of tumor cell nuclei positively stained for ER

64.8 (24.9)

67.2 (25.9)

58.3 (26.9)

65.0 (24.3)

0.35

  ER H-scorec

100.9 (52.8)

105.5 (55.2)

90.0 (58.4)

101.0 (51.5)

0.50

  ER/PR/HER2 scored

–60.3 (41.8)

–54.3 (42.1)

–54.8 (37.4)

–62.7 (42.1)

0.35

  1. Data presented as mean (standard deviation). ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.
  2. aER-positive, ≥1% positively stained tumor cell nuclei.
  3. bThe distribution of age at diagnosis in each subgroup was adjusted according to the distribution of age at diagnosis among the 1,204 participants (35 to 39, 40 to 44, 45 to 49, 50 to 54, 55 to 59, or 60 to 64 years).
  4. cER Histo (H)-score = (% of positively stained tumor cell nuclei at weak intensity category × 1) + (% of positively stained tumor cell nuclei at intermediate intensity category × 2) + (% of positively stained tumor cell nuclei at strong intensity category × 3).
  5. dER/PR/HER2 score = 94.7 × (–0.100 ER10 – 0.079 PR10 + 0.586 HER2).