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Table 1 Descriptive statistics for the measures of estrogen receptor expression by follow-up outcome

From: Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women

  Overall Follow-up outcome
Died from breast cancer Died from other causes Alive at the end of follow-up P F-test
Overall n = 1,204 n = 272 n = 63 n = 869  
ER-positivea (%) 58.0 42.5b 67.0b 61.8b  
Among women with ER-positivea tumor      
  % of tumor cell nuclei positively stained for ER 64.7 (25.5) 62.2 (27.0) 65.6 (24.5) 65.1 (25.2) 0.53
  ER H-scorec 100.8 (53.0) 93.0 (52.9) 104.5 (54.6) 102.2 (52.9) 0.22
  ER/PR/HER2 scored –64.8 (40.6) –49.9 (43.5) –65.7 (34.7) –67.9 (39.8) <0.0001
White women n = 681 n = 131 n = 24 n = 526  
ER-positivea (%) 62.5b 47.2b 78.6b 65.8b  
Among women with ER-positivea tumor      
  % of tumor cell nuclei positively stained for ER 64.6 (25.9) 58.0 (27.4) 74.4 (18.1) 65.2 (25.7) 0.03
  ER H-scorec 100.7 (53.2) 82.3 (48.8) 122.1 (44.9) 102.8 (53.7) 0.004
  ER/PR/HER2 scored –67.6 (39.7) –46.1 (44.7) –78.8 (26.3) –70.8 (38.2) <0.0001
Black women n = 523 n = 141 n = 39 n = 343  
ER-positivea (%) 51.3b 38.0b 60.0b 55.8b  
Among women with ER-positivea tumor      
  % of tumor cell nuclei positively stained for ER 64.8 (24.9) 67.2 (25.9) 58.3 (26.9) 65.0 (24.3) 0.35
  ER H-scorec 100.9 (52.8) 105.5 (55.2) 90.0 (58.4) 101.0 (51.5) 0.50
  ER/PR/HER2 scored –60.3 (41.8) –54.3 (42.1) –54.8 (37.4) –62.7 (42.1) 0.35
  1. Data presented as mean (standard deviation). ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.
  2. aER-positive, ≥1% positively stained tumor cell nuclei.
  3. bThe distribution of age at diagnosis in each subgroup was adjusted according to the distribution of age at diagnosis among the 1,204 participants (35 to 39, 40 to 44, 45 to 49, 50 to 54, 55 to 59, or 60 to 64 years).
  4. cER Histo (H)-score = (% of positively stained tumor cell nuclei at weak intensity category × 1) + (% of positively stained tumor cell nuclei at intermediate intensity category × 2) + (% of positively stained tumor cell nuclei at strong intensity category × 3).
  5. dER/PR/HER2 score = 94.7 × (–0.100 ER10 – 0.079 PR10 + 0.586 HER2).