Variable | 0 to 10 years DEFS | Â | 0 to 5 years DEFS | Â | 5 to 10 years DEFS | Â | |||
---|---|---|---|---|---|---|---|---|---|
 | Hazard ratio (95% CI) | P a | P b | Hazard ratio (95% CI) | P a | P b | Hazard ratio (95% CI) | P a | P b |
Age | 1.02 (1.00, 1.04) | 0.021 | 0.657 | 1.02 (0.99, 1.04) | 0.153 | 0.214 | 1.04 (1.00, 1.08) | 0.042 | 0.168 |
Stage T2/3 vs T1 | 2.71 (1.76, 4.19) | <0.0001 | 0.581 | 2.51 (1.47, 4.26) | 0.0007 | 0.211 | 3.14 (1.49, 6.64) | 0.003 | 0.164 |
Node-positive vs -negative | 2.47 (1.75, 3.48) | <0.0001 | 0.964 | 2.51 (1.65, 3.82) | <0.0001 | 0.732 | 2.67 (1.44, 4.97) | 0.002 | 0.941 |
Grade | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Intermediate vs low | 2.19 (1.20, 3.99) | 0.011 | 0.11 | 3.97 (1.57, 9.99) | 0.003 | 0.175 | 1.04 (0.44, 2.45) | 0.934 | 0.192 |
   High vs low | 2.96 (1.56, 5.62) | 0.0009 | 5.05 (1.92, 13.3) | 0.001 | 1.66 (0.67, 4.12) | 0.277 | |||
HER2-positive vs -negative | 2.64 (1.43, 4.90) | 0.002 | 0.029 | 3.68 (1.91, 7.10) | 0.0001 | 0.369 | 0.72 (0.11, 5.26) | 0.75 | 0.141 |
High MKS vs low MKS | 2.96 (2.07, 4.25) | <0.0001 | 0.04 | 3.89 (2.42, 6.24) | <0.0001 | 0.473 | 1.90 (1.04, 3.46) | 0.036 | 0.377 |
Low ERS vs high ERS | 2.00 (1.41, 2.83) | <0.0001 | 0.0008 | 3.26 (2.04, 5.19) | <0.0001 | 0.091 | 0.91 (0.50, 1.66) | 0.763 | 0.728 |
MKS/ERS combined groups | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   LowMKS/lowERS vs lowMKS/highERS | 2.37 (1.29, 4.35) | 0.005 | <0.0001 | 1.98 (0.87, 4.51) | 0.104 | 0.285 | 3.36 (1.29, 8.73) | 0.013 | 0.862 |
   HighMKS/highERS vs lowMKS/highERS | 3.66 (2.04, 6.57) | <0.0001 | 2.46 (1.09, 5.54) | 0.029 | 6.59 (2.62, 16.6) | <0.0001 | |||
   HighMKS/lowERS vs lowMKS/highERS | 5.35 (3.12, 9.17) | <0.0001 | 7.78 (3.97, 15.3) | <0.0001 | 1.46 (0.45, 4.79) | 0.531 | |||
Other genomic signatures | Â | Â | Â | Â | Â | Â | Â | Â | Â |
High GGI vs low GGI | 2.73 (1.94, 3.86) | <0.0001 | 0.005 | 3.81 (2.43, 5.97) | <0.0001 | 0.296 | 1.64 (0.90, 2.99) | 0.109 | 0.02 |
Mammaprint poor vs good | 2.93 (1.91, 4.49) | <0.0001 | 0.22 | 3.59 (2.02, 6.30) | <0.0001 | 0.768 | 2.30 (1.16, 4.56) | 0.017 | 0.184 |
Three-gene model SCMGENE | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   ER+/HER2-highP vs ER+/HER2-lowP | 2.13 (1.47, 3.08) | <0.0001 | 0.017 | 2.58 (1.59, 4.18) | 0.0001 | 0.585 | 1.60 (0.87, 2.95) | 0.127 | 0.197 |
   HER2+ vs ER+/HER2-lowP | 4.06 (2.09, 7.86) | <0.0001 | 6.63 (3.17, 13.9) | <0.0001 | 0.89 (0.12, 6.64) | 0.909 | |||
   ER-/HER2- vs ER+/HER2-lowP | 2.55 (1.01, 6.42) | 0.048 | 4.70 (1.79, 12.3) | 0.002 | NA |  | |||
PAM50 | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   LumB vs lumA | 3.01 (2.01, 4.51) | <0.0001 | 0.004 | 3.84 (2.21, 6.65) | <0.0001 | 0.109 | 2.26 (1.20, 4.24) | 0.011 | 0.147 |
   HER2 vs lumA | 8.88 (4.36, 18.1) | <0.0001 | 14.4 (6.37, 32.8) | <0.0001 | 2.37 (0.31, 17.9) | 0.403 | |||
   Basal vs lumA | 3.03 (1.07, 8.58) | 0.036 |  | 6.48 (2.17, 19.4) | 0.0008 |  | NA |  |  |