Prognostic values of the four biomarker groups in the second cohort of tamoxifen-treated patients. Kaplan-Meier estimates of 10-year distant event-free survival (DEFS) of the four biomarker groups obtained by combining low and high mitosis kinase score (MKS) and estrogen-related score (ERS) in all patients (A) and node-negative patients (B). Annual hazard rates for distant recurrences by biomarker-group estimates using kernel-based methods for all patients (C). Landmark analyses of the Kaplan-Meier estimates of DEFS during the first 5 years (left side of the panel) and from 5 to 10 years (right side of the panel) is shown for the high-MKS groups by ERS (high and low) (D). loP, low MKS; hiP, high MKS; loER, low ERS; hiER, high ERS).