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Figure 4 | Breast Cancer Research

Figure 4

From: An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models

Figure 4

Lapatinib-resistant cells exhibit a mixed pattern of EGFR tyrosine autophosphorylation. Reverse-phase protein microarray analysis of EGFR Y992, Y1068, Y1148, and Y1173 in parental HER2+ breast cancer cell lines (BT474; SKBR3; Au565; SUM190), parental cells treated with 1 μM lapatinib for 24 hours, and lapatinib-resistant cell counterparts (rBT474; rSKBR3; rAu565; rSUM190) maintained in 1 μM lapatinib. Results represent the mean ± standard error of triplicate samples and are representative of three independent experiments.

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