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Table 3 Risk ratio for ERN, PRN, and HER2P breast cancer

From: Breast cancer receptor status and stage at diagnosis in over 1,200 consecutive public hospital patients in Soweto, South Africa: a case series

   Risk ratio of ERN breast cancer Risk ratio of PRN breast cancer Risk ratio of HER2P breast cancer
Factor Category Crude RR Adjusted RR Crude RR Adjusted RR Crude Adjusted RR
    RR 95% CI   RR 95% CI   RR 95% CI
Age (years) <40 1.08 1.11 0.84, 1.45 1.06 1.06 0.85, 1.32 1.04 1.02 0.76, 1.38
40–49 (ref) 1 1 - 1 1 - 1 1 -
50–59 1.38 1.33 1.08, 1.65 1.39 1.37 1.16, 1.61 0.74 0.74 0.56, 0.99
60–69 0.93 0.92 0.70, 1.20 1.01 1.03 0.83, 1.26 0.75 0.75 0.54, 1.03
70–79 0.96 0.95 0.70, 1.29 0.86 0.87 0.67, 1.13 0.79 0.80 0.56, 1.15
≥80 0.91 0.89 0.57, 1.38 0.92 0.86 0.60, 1.23 0.49 0.49 0.25, 0.94
per 5 years 0.99 0.99 0.95, 1.02 0.99 0.99 0.97, 1.01 0.95 0.95 0.92, 0.99
    P t = 0.37    P t = 0.27    p t = 0.01
Calendar year 2006–2007 1.10 1.05 0.84, 1.32 0.97 0.91 0.76, 1.08 0.97 0.94 0.69, 1.28
2008–2009 (ref) 1 1 - 1 1 - 1 1 -
2010–2012 0.86 0.84 0.71, 1.00 0.84 0.82 0.72, 0.94 0.71 0.70 0.56, 0.88
    P = 0.03    P t = 0.09    p = 0.01
Stage I (ref) 1 1 - 1 1 - 1 1 -
II 1.25 1.23 0.75, 2.02 1.47 1.55 1.00, 2.41 0.83 0.89 0.54, 1.44
III 1.84 1.76 1.08, 2.85 1.92 1.99 1.29, 3.09 1.15 1.22 0.76, 1.98
IV 1.52 1.48 0.85, 2.57 1.93 1.92 1.20, 3.07 1.11 1.19 0.67, 2.11
    P t = 0.001    P t = 0.001    p t = 0.05
Tumor grade 1 (ref) 1 1 - 1 1   1 1 -
2 2.09 1.94 1.11, 3.37 1.48 1.42 0.99, 2.04 1.48 1.30 0.79, 2.15
3 4.40 3.95 2.30, 6.79 2.52 2.37 1.67, 3.36 2.12 1.80 1.10, 2.95
Missing 3.14 2.83 1.58, 5.04 2.18 1.96 1.34, 2.86 1.82 1.63 0.93, 2.86
          p = 0.01
Ethnicity Black (ref) 1 1 - 1 1 - 1 1 -
Nonblacka 0.61 0.61 0.42, 0.89 0.71 0.73 0.55, 0.95 0.89 0.86 0.59, 1.25
    P = 0.009    P = 0.02    p = 0.42
White 0.55 0.55 0.29, 1.01 0.67 0.69 0.44, 1.07 0.91 0.87 0.49, 1.55
Colored 0.63 0.63 0.35, 1.11 0.69 0.70 0.45, 1.09 0.81 0.77 0.41, 1.43
Asian 0.68 0.72 0.34,1.53 0.83 0.81 0.48, 1.38 1.01 0.99 0.47, 2.09
    P = 0.08    P = 0.13    p = 0.86
  1. Note: Analyses based on 1,063 women for ER, 1,058 for PR, and 1,021 for HER2. Adjusted RRs are adjusted for age, stage, year, and race, unless this is the variable of interest. P values denote test of heterogeneity across categories; Pt denotes test of linear trend.
  2. aNonblack women are the combined group of white, colored, and Asian women.
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