Hepatocyte growth factor signaling is present in vivo in basal-like tumors. An in vitro generated signature that captures hepatocyte growth factor (HGF) signaling is highly correlated with invasive basal-like tumors. (A) Number of tumors that are positively and negatively correlated with the HGF signature by subtype. (B) Creighton correlation of each basal-like and luminal tumor with the HGF signature; the degree of positivity among basal-like tumors is higher when compared with the luminal tumors (scale bar). (C) Kaplan–Meier survival curves for overall survival among patients that were positive or negative for the HGF signature. Patients with basal-like tumors with positive HGF signatures had worse overall survival over a period of 14 years.