Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 3 wGRS results of antimicrotubule agents, docetaxel, and paclitaxel-induced alopecia

From: A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients

Cat Score G2a G1b G0c %-G2 %-G1 %-G0   G2 vs. G0   G1 vs. G0
         ORd* 95%CI Pvalue ORd* 95%CI Pvalue
Antimicrotubule (6 SNPs)              
1 <5.56 2 7 34 0.05 0.16 0.79   Ref    Ref  
2 5.56-7.60 25 20 50 0.26 0.21 0.53 8.50 1.89-38.3 1.66E-03 1.94 0.74-1.42 2.52E-01
3 7.60-9.63 65 17 19 0.64 0.17 0.19 58.2 12.8-265 4.93E-14 4.35 1.53-12.4 6.42E-03
4 >9.63 26 6 1 0.79 0.18 0.03 442 38.0-5140 2.71E-14 29.1 3.02-282 8.39E-04
  Total 118 50 104          
Docetaxel (4 SNPs)              
1 <2.26 1 5 23 0.03 0.17 0.79   Ref    Ref  
2 2.26-4.70 9 6 14 0.31 0.21 0.48 14.8 1.69-130 4.39E-03 1.97 0.51-7.68 4.88E-01
3 4.70-7.15 33 5 4 0.79 0.12 0.10 190 19.9-1810 1.01E-11 5.75 1.12-29.4 4.08E-02
4 >7.15 19 2 0 0.90 0.10 0.00 611 23.5-15900 2.50E-11 21.4 0.89-511 4.83E-02
  Total 62 18 41          
Paclitaxel (7 SNPs)              
1 <3.24 2 4 28 0.06 0.12 0.82   Ref    Ref  
2 3.24-7.48 4 14 22 0.10 0.35 0.55 2.55 0.43-15.2 4.01E-01 4.46 1.28-1.92 2.60E-02
3 7.48-11.7 35 12 11 0.60 0.21 0.19 44.6 9.12-218 9.55E-10 7.64 2.02-28.9 2.30E-03
4 >11.7 16 5 0 0.76 0.24 0.00 376 17.0-8320 1.54E-10 69.7 3.26-1490 2.89E-04
  Total 57 35 61          
  1. aIndividuals who developed grade 2 alopecia; bindividuals who developed grade 1 alopecia; cindividuals who did not developed any ADRs after chemotherapy; dORs and CIs are calculated using category (group) 1 as reference. *OR calculated after Haldane’s correction: adding 0.5 to all the cells of a contingency table if any of the cell expectations would cause a division by zero error. Cat, category; OR, odds ratio; CI, confidence interval; Ref, reference.