Table 4 Expression of metabolism-related proteins according to breast cancer phenotype a
Parameters | Total | Luminal A | Luminal B | HER2 | TNBC | P-value |
|---|---|---|---|---|---|---|
(N= 740 ) (%) | (n= 298 ) (%) | (n= 166) (%) | (n= 69) (%) | (n= 207) (%) | ||
Glut-1 in tumor | Â | Â | Â | Â | Â | <0.001 |
 Negative | 504 (68.1) | 260 (87.2) | 124 (74.7) | 47 (68.1) | 73 (35.3) |  |
 Positive | 236 (31.9) | 38 (12.8) | 42 (25.3) | 22 (31.9) | 134 (64.7) |  |
Glut-1 in stroma | Â | Â | Â | Â | Â | 0.103 |
 Negative | 724 (97.8) | 296 (99.3) | 162 (97.6) | 66 (95.7) | 200 (96.6) |  |
 Positive | 16 (2.2) | 2 (0.7) | 4 (2.4) | 3 (4.3) | 7 (3.4) |  |
CAIX in tumor | Â | Â | Â | Â | Â | 0.008 |
 Negative | 520 (70.3) | 217 (72.8) | 127 (76.5) | 49 (71.0) | 127 (61.3) |  |
 Positive | 220 (29.7) | 81 (27.2) | 39 (23.5) | 20 (29.0) | 80 (38.6) |  |
CAIX in stroma | Â | Â | Â | Â | Â | 0.032 |
 Negative | 627 (84.7) | 264 (88.6) | 137 (82.5) | 52 (75.4) | 174 (84.1) |  |
 Positive | 113 (15.3) | 34 (11.4) | 29 (17.5) | 17 (24.6) | 33 (15.9) |  |
ATP synthase in tumor | Â | Â | Â | Â | Â | 0.027 |
 Negative | 30 (4.1) | 20 (6.7) | 4 (2.4) | 1 (1.4) | 5 (2.4) |  |
 Positive | 710 (95.9) | 278 (93.3) | 162 (97.6) | 68 (98.6) | 202 (97.6) |  |
ATP synthase in stroma | Â | Â | Â | Â | Â | <0.001 |
 Negative | 570 (77.0) | 256 (85.9) | 112 (67.5) | 38 (55.1) | 164 (79.2) |  |
 Positive | 170 (23.0) | 42 (14.1) | 54 (32.5) | 31 (44.9) | 43 (20.8) |  |
Glutaminase in tumor | Â | Â | Â | Â | Â | 0.164 |
 Negative | 219 (29.6) | 85 (28.5) | 60 (36.1) | 21 (30.4) | 53 (25.6) |  |
 Positive | 521 (70.4) | 213 (71.5) | 106 (63.9) | 48 (69.6) | 154 (74.4) |  |
Glutaminase in stroma | Â | Â | Â | Â | Â | 0.001 |
 Negative | 495 (66.9) | 223 (74.8) | 105 (63.3) | 39 (56.5) | 128 (61.8) |  |
 Positive | 245 (33.1) | 75 (25.2) | 61 (36.7) | 30 (43.5) | 79 (38.2) |  |
BNIP3 in tumor | Â | Â | Â | Â | Â | 0.262 |
 Negative | 504 (68.1) | 206 (69.1) | 112 (67.5) | 40 (58.0) | 146 (70.5) |  |
 Positive | 236 (31.9) | 92 (30.9) | 54 (32.5) | 29 (42.0) | 61 (29.5) |  |
BNIP3 in stroma | Â | Â | Â | Â | Â | 0.262 |
 Negative | 700 (94.6) | 281 (94.3) | 159 (95.8) | 62 (89.9) | 198 (95.7) |  |
 Positive | 40 (5.4) | 17 (5.7) | 7 (4.2) | 7 (10.1) | 9 (4.3) |  |
MCT4 in tumor | Â | Â | Â | Â | Â | <0.001 |
 Negative | 540 (73.0) | 253 (84.9) | 118 (71.1) | 49 (71.0) | 120 (58.0) |  |
 Positive | 200 (27.0) | 45 (15.1) | 48 (28.9) | 20 (29.0) | 87 (42.0) |  |
MCT4 in stroma | Â | Â | Â | Â | Â | <0.001 |
 Negative | 418 (56.5) | 222 (74.5) | 81 (48.8) | 23 (33.3) | 92 (44.4) |  |
 Positive | 322 (43.5) | 76 (25.5) | 85 (51.2) | 46 (66.7) | 115 (55.6) |  |
Cytoplasmic Beclin-1 | Â | Â | Â | Â | Â | 0.137 |
 Negative | 406 (54.9) | 169 (56.7) | 99 (59.6) | 31 (44.9) | 107 (51.7) |  |
 Positive | 334 (45.1) | 129 (43.3) | 67 (33.7) | 38 (55.1) | 100 (48.3) |  |
Nuclear Beclin-1 | Â | Â | Â | Â | Â | <0.001 |
 Negative | 666 (90.0) | 262 (87.9) | 152 (91.6) | 55 (79.7) | 197 (95.2) |  |
 Positive | 74 (10.0) | 36 (12.1) | 14 (8.4) | 14 (20.3) | 10 (4.8) |  |
LC3A in tumor | Â | Â | Â | Â | Â | <0.001 |
 Negative | 669 (90.4) | 294 (98.7) | 158 (95.2) | 68 (98.6) | 149 (72.0) |  |
 Positive | 71 (9.6) | 4 (1.3) | 8 (4.8) | 1 (1.4) | 58 (28.0) |  |
LC3A in stroma | Â | Â | Â | Â | Â | <0.001 |
 Negative | 687 (92.8) | 267 (89.6) | 151 (91.0) | 62 (89.9) | 207 (100.0) |  |
 Positive | 53 (7.2) | 31 (10.4) | 15 (9.0) | 7 (10.1) | 0 (0.0) |  |
LC3B in tumor | Â | Â | Â | Â | Â | 0.013 |
 Negative | 475 (64.2) | 186 (62.4) | 124 (74.7) | 42 (60.9) | 123 (59.4) |  |
 Positive | 265 (35.8) | 112 (37.6) | 42 (25.3) | 27 (39.1) | 84 (40.6) |  |
LC3B in stroma | Â | Â | Â | Â | Â | 0.645 |
 Negative | 688 (93.0) | 277 (93.0) | 151 (91.0) | 65 (94.2) | 195 (94.2) |  |
 Positive | 52 (7.0) | 21 (7.0) | 15 (9.0) | 4 (5.8) | 12 (5.8) |  |
Cytoplasmic p62 in tumor | Â | Â | Â | Â | Â | <0.001 |
 Negative | 274 (37.0) | 131 (44.0) | 51 (30.7) | 15 (21.7) | 77 (37.2) |  |
 Positive | 466 (63.0) | 167 (56.0) | 115 (69.3) | 54 (78.3) | 130 (62.8) |  |
Nuclear p62 in tumor | Â | Â | Â | Â | Â | <0.001 |
 Negative | 532 (71.9) | 180 (60.4) | 131 (78.9) | 44 (63.8) | 177 (85.5) |  |
 Positive | 208 (28.1) | 118 (39.6) | 35 (21.1) | 25 (36.2) | 30 (14.5) |  |
Nuclear p62 in stroma | Â | Â | Â | Â | Â | 0.876 |
 Negative | 512 (69.2) | 206 (69.1) | 115 (69.3) | 45 (65.2) | 146 (70.5) |  |
 Positive | 228 (30.8) | 92 (30.9) | 51 (30.7) | 24 (34.8) | 61 (29.5) |  |