Figure 1From: Metabolic interaction between cancer cells and stromal cells according to breast cancer molecular subtypeHistologic and immunohistochemical features according to metabolic phenotypes of breast cancer. The Warburg and mixed types show high histologic grade, estrogen receptor (ER) negativity and high Ki-67 labeling index (LI). In contrast, the reverse Warburg and null types show low histologic grade, ER positivity and low Ki-67 LI. ATP synthase and glutaminase were high in the reverse Warburg and mixed types and low in the Warburg and null types (P < 0.001). BNIP3, BCL2/adenovirus E1B 19-kDa interacting protein 3; CAIX, carbonic anhydrase IX; GLUT1, glucose transporter 1; H & E, hematoxylin and eosin; MCT4, monocarboxylate transporter 4.Back to article page