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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for case-case analyses comparing the association with BI-RADS-measured mammographic density by breast cancer risk subtypes

From: Association between mammographic density and basal-like and luminal A breast cancer subtypes

  Basal-like versus luminal A Triple-negative versus luminal A
  Model 1a Model 2b Model 1 Model 2
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
Almost entirely fat 1.00 (Referent) 1.05 (0.10, 10.97) 1.00 (Referent) 0.33 (0.03, 3.95)
Scattered fibroglandular densities 0.95 (0.09, 9.90) 1.00 (Referent) 3.05 (0.25, 36.68) 1.00 (Referent)
Heterogeneously dense 0.63 (0.06, 6.65) 0.67 (0.30, 1.49) 2.62 (0.22, 31.62) 0.86 (0.44, 1.67)
Extremely dense 1.02 (0.08, 13.50) 1.08 (0.30, 3.84) 3.57 (0.26, 49.11) 1.17 (0.41, 3.35)
  Ptrend = 0.66c Ptrend = 0.74
  1. aModel 1 is adjusted for age, race, body mass index, menopausal status, family history of breast cancer, age at menarche, use of hormone therapy, and parity and age at first full-term pregnancy combined, where BI-RADS category 1 (almost entirely fat) is the referent group; bModel 2 is adjusted for the same variables as Model 1 but BI-RADS category 2 (scattered fibroglandular densities) is the referent group; cP-value for trend test is based on the likelihood ratio test statistic and is two-sided. The same ordinal model was fit to assess the P-value for trend of Model 1 and Model 2. BI-RADS, Breast Imaging Reporting and Data System.