Skip to main content
Figure 6 | Breast Cancer Research

Figure 6

From: Mammary Carcinoma Cell Derived Cyclooxygenase 2 Suppresses Tumor Immune Surveillanceby Enhancing Intratumoral Immune Checkpoint Activity

Figure 6

CD8+ cell depletion restores growth of injected NAF COX-2KD tumorcells as orthotopic tumors. (A) Flow cytometry of peripheral blood fromanti-CD8 or isotype control antibody treated mice four days after mammary fatpad injection (representative of n = 6). (B) Tumor growth of NAF ntand NAF COX-2KD cells injected into mammary fat pads of mice that receivedeither anti-CD8 or isotype control antibody injection (antibody treatmentdenoted with ^ along X axis; n = 6). (C) NAF COX-2KD tumor volumemeasured on necropsy of animals that were treated with either isotype controlor anti-CD8 antibody. In B and C data are mean ± sem of n = 6.**P < 0.005, ***P < 0.0005. COX, cyclooxygenase.

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us