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Figure 4 | Breast Cancer Research

Figure 4

From: Mammary Carcinoma Cell Derived Cyclooxygenase 2 Suppresses Tumor Immune Surveillanceby Enhancing Intratumoral Immune Checkpoint Activity

Figure 4

COX-2 suppresses immune surveillance by altering T cell recruitment andactivation. COX-2MECKO tumors are denoted as KO. (A) Immunohistochemistry staining for CXCL9 (brown) of sections from paraffinembedded WT and COX-2MECKO tumors (two images from each genotypeshown are representative of n = 4). Nuclei are counterstained withhematoxylin. The bar on the KO panel corresponds to 40× magnification.(B) Gene expression levels measured by Q-PCR in whole tumors (n = 8 to 18). Data are mean ± sem. P values are compared toWT; *P < 0.05. COX, cyclooxygenase; KO, knock out; WT, wildtype.

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