Figure 2

Angiogenesis was suppressed in COX-2^MECKO tumors.COX-2^MECKO tumors are denoted as KO. (A) Gene expressionlevels for CD31, eNOS, VEGFA, VEGFC, VEGFR2 and VEGFR3 in whole tumors byQ-PCR. Data are mean ± sem of n = 8 to 18. P values arecompared to WT. *P < 0.05. (B) Immunohistochemistry stainingfor CD31 (dark red-brown) in sections of paraffin embedded WT andCOX-2^MECKO tumors (image is representative of n = 6).Cell nuclei are counterstained with hematoxylin. The bar on the KO panelindicates 20× magnification. COX, cyclooxygenase; KO, knock out; WT, wildtype.