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Figure 2 | Breast Cancer Research

Figure 2

From: Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment

Figure 2

Prolactin signaling in breast cancer cells is markedly inhibited by moderate acidic pH e . (A) T47D cells and SKBR3 cells were induced by prolactin or vehicle at pHe 7.4 or 6.8. All major prolactin signaling pathways were examined. T47D (B) and SKBR3 (C) cells were induced by prolactin or vehicle at various pHe as indicated. Stat5 and Erk activation by prolactin was examined. Levels of Stat5 activation were analyzed by densitometry and plotted as mean ± SE (n = 3). The pYStat5 levels among different pHe conditions were analyzed by ANOVA, and followed by Fisher’s least significant difference test. ANOVA, analysis of variance; pHe, extracellular pH; SE, standard error. *, p <0.05; **, p <0.01; ***, p <0.001.

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