Table 1 NCIC CTG MA

    I. Placebo Arm

Cox Model for All Patients:

All IHC values

IHC

0.27

0.08

N/A

N/A

N/A

Standardized IHC

0.96

0.07

N/A

N/A

N/A

qPCR

N/A

N/A

0.12

0.02

N/A

Standardized qPCR

N/A

N/A

0.12

0.02

N/A

IHC and qPCR

0.08

0.41

0.03

0.15

N/A

Standardized IHC and qPCR

0.40

0.19

0.12

0.47

N/A

Cox Model for Patients with

Positive IHC ER and/or PgR

IHC

0.25

0.29

N/A

N/A

N/A

Standardized IHC

0.53

0.07

N/A

N/A

N/A

qPCR

N/A

N/A

0.23

0.01

N/A

Standardized qPCR

N/A

N/A

0.23

0.01

N/A

IHC and qPCR

0.01

0.67

0.04

0.01

N/A

Standardized IHC and qPCR

0.21

0.50

0.11

0.04

N/A

    II. Tamoxifen Arm

Cox Model for All Patients:

All IHC values

IHC

0.18

0.61

N/A

N/A

N/A

Standardized IHC

0.44

0.89

N/A

N/A

N/A

qPCR

N/A

N/A

0.46

0.83

N/A

Standardized qPCR

N/A

N/A

0.46

0.83

N/A

IHC and qPCR

0.26

0.69

0.79

0.95

N/A

Standardized IHC and qPCR

0.50

0.58

0.75

0.48

N/A

Cox Model for Patients with

Positive IHC ER and/or PgR

IHC

0.30

0.57

N/A

N/A

N/A

Standardized IHC

0.37

0.82

N/A

N/A

N/A

qPCR

N/A

N/A

0.22

0.19

N/A

Standardized qPCR

N/A

N/A

0.22

0.19

N/A

IHC and qPCR

0.75

0.57

0.34

0.20

N/A

Standardized IHC and qPCR

0.67

0.14

0.22

0.07

N/A

    III. Both Arms Together

Cox Model for All Patients:

All IHC values

IHC

0.20

0.45

N/A

N/A

0.003

Standardized IHC

0.63

0.21

N/A

N/A

0.004

qPCR

N/A

N/A

0.66

0.20

0.004

Standardized qPCR

N/A

N/A

0.45

0.19

0.003

IHC and qPCR

0.07

0.75

0.15

0.48

0.002

Standardized IHC and qPCR

0.28

0.22

0.20

0.99

0.003

Cox Model for Patients with

Positive IHC ER and/or PgR

IHC

0.18

0.43

N/A

N/A

0.004

Standardized IHC

0.47

0.05

N/A

N/A

0.005

qPCR

N/A

N/A

0.75

0.30

0.005

Standardized qPCR

N/A

N/A

0.75

0.30

0.005

IHC and qPCR

0.07

0.75

0.25

0.53

0.002

Standardized IHC and qPCR

0.34

0.10

0.55

0.97

0.005