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Table 4 Comparison of PIK3CA mutation studies in male and female breast cancer

From: PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

 

Male Breast Cancer

Female Breast Cancer

 

Current Study

Benvenuti S et al. [20]

Benvenuti S et al. [20]

Buttitta F et al. [14]

Campbell IG et al. [3]

Saal H et al. [16]

Study population

High risk - familial

Population based

Population based

Population based

Population based

Population based

Frequency

6/57 (10.5%)

7/39 (17.9%)

14/86 (16.3%)

46/180 (25.6%)

28/70 (40.0%)

77/292 (26.4%)

Mutation Locus

3 exon 9, 3 exon 20

7 exon 20

6 exon 9, 8 exon 20

23 exon 9, 23 exon 20

15 exon 9, 9 exon 20, 3 exon 7, 1 exon 6

31 exon 9, 49 exon 20, 7 exon 7, 7 others

Clinicopathological association

Inverse correlation with BRCA2 mutation carrier status

No clinicopathological association

No clinicopathological association

Mutation seen more frequently in lobular carcinoma (46%, P < 0.001). Exon 9 more frequently seen in lobular carcinoma (30% of cases, P < 0.001).

No clinicopathological association

Association with ER positivity (P = 0.0001), PgR Positivity (0.0063) and lymph node positivity (P = 0.0375).

  1. P-values < 0.05 in bold text