Table 2 Correlation of PIK3CA mutation status with clinicopathological parameters
From: PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer
| Â | PIK3CAMutation (n = 6) | PIK3CAWild type (n = 51) | P-value |
|---|---|---|---|
Age - mean (years) | 62.2 | 63.0 | 0.899 |
Overall DSS | 33.3% | 33.3% | 1.000 |
Carrier mutation status | Â | Â | Â |
BRCA1 | 1 | 2 | 0.288 |
BRCA2 | 0 | 25 | 0.030 |
BRCAX | 5 | 24 | 0.194 |
Primary tumour size (mm) | 18.8 | 19.1 | 0.948 |
Histological type | Â | Â | Â |
Invasive carcinoma - no special type (IC - NST) | 6 | 37 | 0.319 |
IC-NST with micropapillary areas | 0 | 9 | 0.575 |
Invasive Papillary Carcinoma | 0 | 3 | 1.000 |
Invasive Lobular Carcinoma | 0 | 2 | 1.000 |
Tumour grade | Â | Â | Â |
1 | 0 | 3 | 1.000 |
2 | 3 | 26 | 1.000 |
3 | 3 | 22 | 1.000 |
Lymphovascular invasion | 33.3% | 39.2% | 1.000 |
Perineural invasion | 50.0% | 41.2% | 0.689 |
Intrinsic subtype | Â | Â | Â |
Luminal | 6 | 45 | 1.000 |
HER2 | 0 | 5 | 1.000 |
Basal | 0 | 1 | 1.000 |
Null | 0 | 0 | 1.000 |