Figure 9
From: LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Elevated LOXL2 and ErbB2 are associated with invasive cell behavior and poor patient prognosis. (A) Disease-specific genomic analysis (DSGA) was performed on gene-expression microarray data from the NKI cohort [17]. Of 295 tumors, 51 were found to express high levels of ErbB2, and a Kaplan-Meier survival curve is constructed from this subset of ErbB2-positive tumors. Shown here is the overall survival of patients with Her2/ErbB2-positive tumors (n = 51) separated into low and high LOXL2 expression. P = 0.017. (B) As in Figure 8A, showing metastasis-free survival. P = 0.026.