LOXL2 promotes invasion of normal breast epithelial cells; this effect is abrogated with ErbB2 inhibition. (A) The 10A L2 cells exhibited increased invasion through Matrigel compared with 10A cont cells in Transwell invasion assays. (B) Herceptin treatment reduced the invasive ability of the 10A L2 cells to a level comparable to 10A cont cells. Human IgG treatment had no effect on the invasiveness of the manipulated 10A cells. (C) Lapatinib treatment of the 10A L2 cells greatly reduced the invasiveness of the cells to a level comparable to the 10A cont cells. DMSO treatment had no effect on the invasive properties of the manipulated 10A cells.