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Table 4 Odds ratio of CBC in relation to changes in mammographic density after first breast cancer

From: Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study

Post-diagnostic change of density    
Percent density N OR* 95% CI OR** 95% CI
Absolute decrease ≥10% 96 0.49 0.28 to 0.85 0.45 0.24 to 0.84
Stable (<10% decrease to <10% increase) 243 1.00 Ref. 1.00 Ref.
Absolute increase ≥10% 17 0.74 0.23 to 2.40 0.83 0.24 to 2.87
P -value for trend***   0.04   0.04  
Area density N OR* 95% CI OR** 95% CI
Absolute decrease ≥10 cm 2 108 0.67 0.38 to 1.16 0.54 0.30 to 0.99
Stable (<10 cm 2 decrease to <10 cm 2 increase) 197 1.00 Ref. 1.00 Ref.
Absolute increase ≥10 cm 2 33 0.79 0.35 to 1.78 0.71 0.30 to 1.69
P -value for trend***   0.35   0.13  
  1. * Adjusted through matching for age at diagnosis, calendar period of diagnosis, adjuvant therapy and follow-up time.
  2. ** Adjusted through matching for age at diagnosis, calendar period of diagnosis, adjuvant therapy and follow-up time, and additionally in the analyses for percent density and non-dense area at first diagnosis.
  3. *** Trend test is based on the ordered categories of change of percent density and dense area, respectively
  4. Patients with <10% or >90% percent mammographic density at baseline (N = 66), or those with <10 cm2 or >70 cm2 dense area (N = 84), were excluded, since they cannot possibly undergo changes in percent mammographic density, or dense area, of the defined magnitude A similar strategy has previously been used by others when studying changes in mammographic density [5].