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Table 5 Odds ratios and 95% confidence intervals comparing odds of breast cancer associated with each polymorphism among women with less than two consecutive night shifts for 5 or more years compared to women with three consecutive night shifts or women with four or more consecutive night shifts for 5 or more years

From: Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts

Genes and SNPs

Number of consecutive night shifts nurse has ever worked for 5 or more years

 

0 to 2 consecutive nights

3 consecutive nights

4 or more consecutive nights

 

Caa/Coa

OR (95% CI)b

Caa/Coa

OR (95% CI)b Pinterc

FPRPd BFDPe

Caa/Coa

OR (95% CI)b Pinterc

FPRPd BFDPe

ARNTL1/

BMAL1

        

rs2290035

        

TT

106/121

1.0 (reference)

40/46

0.98 (0.58 - 1.65)

 

26/26

0.99 (0.53 - 1.88)

 

TA

149/161

1.03 (0.72 - 1.47)

66/71

1.04 (0.71 - 1.51)

 

46/50

1.02 (0.66 - 1.57)

 

AA

50/61

0.95 (0.59 - 1.52)

16/27

0.69 (0.36 - 1.34)

 

36/21

1.91 (1.08 - 3.37) 0.03

0.12 0.19

    

Ptrendf = 0.60

  

Ptrendf = 0.08

 

TT

106/121

1.0 (reference)

40/46

0.98 (0.58 - 1.65)

 

26/26

0.99 (0.53 - 1.88)

 

TA

149/161

1.0 (reference)

66/71

0.99 (0.65 - 1.50)

 

46/50

1.10 (0.64 - 1.63)

 

AA

50/61

1.0 (reference)

16/27

0.75 (0.35 - 1.60)

 

36/21

1.95 (0.97 - 3.90) 0.06

0.25 0.24

rs2278749

        

CC

212/231

1.0 (reference)

97/92

1.19 (0.84 - 1.70)

 

66/58

1.26 (0.83 - 1.91)

 

CT

86/87

1.19 (0.83 - 1.73)

22/45

0.51 (0.29 - 0.87) 0.01

0.07 0.15

33/32

1.10 (0.64 - 1.84)

 

TT

7/19

0.40 (0.16 - 0.98)

1/5

0.26 (0.03 - 2.38)

 

5/6

0.84 (0.25 - 2.82)

 
    

Ptrendf = 0.07

  

Ptrendf = 0.52

 

CC

212/231

1.0 (reference)

97/92

1.19 (0.84 - 1.70)

 

66/58

1.26 (0.83 - 1.91)

 

CT

86/87

1.0 (reference)

22/45

0.47 (0.25 - 0.88) 0.02

0.12 0.18

33/32

0.99 (0.55 - 1.79)

 

TT

7/19

1.0 (reference)

1/5

1.33 (0.10 - 17.78)

 

5/6

2.68 (0.48 - 15.01)

 

rs969485

        

AA

161/189

1.0 (reference)

51/74

0.83 (0.54 - 1.28)

 

41/50

0.92 (0.57 - 1.49)

 

AG

105/117

1.05 (0.74 - 1.49)

58/55

1.23 (0.82 - 1.85)

 

50/35

1.64 (1.03 - 2.61) 0.04

0.12 0.18

GG

21/20

1.07 (0.54 - 2.09)

8/8

1.40 (0.50 - 3.94)

 

9/7

1.50 (0.53 - 4.22)

 
    

Ptrendf = 0.49

  

P trend f = 0.05

 

AA

161/189

1.0 (reference)

51/74

0.83 (0.54 - 1.28)

 

41/50

0.92 (0.57 to 1.49)

 

AG

105/117

1.0 (reference)

58/55

1.50 (0.72 - 1.85)

 

50/35

1.63 (0.96 - 2.76) 0.07

0.21 0.23

GG

21/20

1.0 (reference)

8/8

1.35 (0. 37 - 4.88)

 

9/7

1.60 (0.38 - 6.74)

 

ARNTL2/

BMAL2

        

rs2306074

        

TT

143/144

1.0 (reference)

58/63

0.91 (0.59 - 1.43)

 

51/53

0.97 (0.61 - 1.53)

 

TC

134/163

0.84 (0.60 - 1.17)

60/68

0.97 (0.66 - 1.42)

 

50/40

1.36 (0.86 - 2.13)

 

CC

37/39

1.04 (0.61 - 1.76)

6/21

0.30 (0.17 - 0.75) 0.01

0.18 0.21

9/9

1.03 (0.39 - 2.72)

 
    

Ptrendf = 0.06

  

Ptrendf = 0.51

 

TT

143/144

1.0 (reference)

58/63

0.91 (0.59 - 1.43)

 

51/53

0.97 (0.61 - 1.53)

 

TC

134/163

1.0 (reference)

60/68

1.06 (0.68 - 1.64)

 

50/40

1.37 (0.83 - 2.26)

 

CC

37/39

1.0 (reference)

6/21

0.24 (0.08 - 0.77) 0.02

0.31 0.25

9/9

0.99 (0.32 - 3.11)

 

CLOCK

        

rs3749474

        

CC

123/131

1.0 (reference)

52/55

0.97 (0.68 - 1.37)

 

48/42

1.08 (0.73 - 1.59)

 

CT

148/152

1.04 (0.74 - 1.47)

56/63

0.87 (0.46 - 1.63)

 

47/45

1.84 (0.92 - 3.69)

 

TT

39/66

0.60 (0.37 - 0.97)

16/29

0.24 (0.05 - 1.18) 0.07

0.56 0.29

13/13

3.15 (0.62 - 16.14)

 
    

Ptrendf = 0.24

  

Ptrendf = 0.63

 

CC

123/131

1.0 (reference)

52/55

0.97 (0.68 - 1.37)

 

48/42

1.08 (0.73 - 1.59)

 

CT

148/152

1.0 (reference)

56/63

0.64 (0.30 - 1.36)

 

47/45

1.44 (0.63 - 3.31)

 

TT

39/66

1.0 (reference)

16/29

0.30 (0.05 - 1.77)

 

13/13

2.12 (0.30 - 15.15)

 

CSNK1E

        

rs1534891

        

GG

241/258

1.0 (reference)

98/112

0.93 (0.66 - 1.309)

 

82/76

1.12 80.77 - 1.62)

 

GA

62/77

0.83 (0.57 - 1.23)

17/35

0.55 (0.30 - 1.01) 0.05

0.21 0.23

25/25

1.09 (0.61 - 1.95)

 

AA

5/9

0.51 (0.16 - 1.60)

2/1

2.00 (0.17 - 23.92)

 

1/2

0.39 (0.03 - 4.68)

 
    

Ptrendf = 0.13

  

Ptrendf = 0.66

 

GG

241/258

1.0 (reference)

98/112

0.93 (0.66 - 1.309)

 

82/76

1.12 80.77 - 1.62)

 

GA

62/77

1.0 (reference)

17/35

0.63 (0.31 - 1.28)

 

25/25

1.11 (0.56 - 2.21)

 

AA

5/9

1.0 (reference)

2/1

2.58 (0.14 - 91.16)

 

1/2

2.84 (0.08 - 96.47)

 

rs5757037

        

CC

126/154

1.0 (reference)

49/57

1.10 (0.68 - 1.76)

 

41/38

1.28 (0.75 - 2.70)

 

CT

137/140

1.11 (0.79 - 1.58)

51/77

0.67 (0.45 - 0.99) 0.05

0.13 0.18

49/45

1.14 (0.74 - 1.77)

 

TT

43/43

1.04 (0.63 - 1.71)

14/16

0.90 (0.43 - 1.90)

 

16/16

1.00 (0.49 - 2.05)

 
    

Ptrendf = 0.57

  

Ptrendf = 0.22

 

CC

126/154

1.0 (reference)

49/57

1.10 (0.68 - 1.76)

 

41/38

1.28 (0.75 - 2.70)

 

CT

137/140

1.0 (reference)

51/77

0.65 (0.42 - 1.02)

 

49/45

1.08 (0.66 - 1.75)

 

TT

43/43

1.04 (0.63- 1.71)

14/16

0.89 (0.38 - 2.10)

 

16/16

0.97 (0.42 - 2.23)

 

NPAS2

        

rs2305160

        

GG

136/134

1.0 (reference)

52/57

0.86 (0.54 - 1.36)

 

50/42

1.15 (0.70 - 1.88)

 

GA

130/151

0.84 (0.59 - 1.18)

51/69

0.84 (0.56 - 1.25)

 

43/41

1.10 (0.70 - 1.74)

 

AA

41/56

0.72 (0.45 - 1.18)

18/21

0.87 (0.45 - 1.69)

 

14/13

1.22 (0.56 - 2.64)

 
    

Ptrendf = 0.21

  

Ptrendf = 0.79

 

rs2305160

        

GG

136/134

1.0 (reference)

52/57

0.86 (0.54 - 1.36)

 

50/42

1.15 (0.70 - 1.88)

 

GA

130/151

1.0 (reference)

51/69

0.95 (0.61 - 1.50)

 

43/41

1.19 (0.72 - 1.96)

 

AA

41/56

1.0 (reference)

18/21

1.10 (0.50 - 2.40)

 

14/13

1.43 (0.58 - 3.52)

 

rs17024926

        

TT

110/133

1.0 (reference)

60/66

1.22 (0.78 - 1.92)

 

36/45

1.03 (0.61 - 1.75)

 

TC

148/178

1.08 (0.76 - 1.52)

55/64

0.98 (0.66 - 1.47)

 

54/46

1.23 (0.80 - 1.89)

 

CC

47/38

1.51 (0.90 - 2.52)

6/21

0.33 (0.13 - 0.84) 0.020

0.24 0.23

17/10

1.89 (0.85 - 4.23)

 
    

Ptrendf = 0.28

  

P trend f = 0.05

 

TT

110/133

1.0 (reference)

60/66

1.22 (0.78 - 1.92)

 

36/45

1.03 (0.61 - 1.75)

 

TC

148/178

1.0 (reference)

55/64

1.01 (0.65 - 1.57)

 

54/46

1.28 (0.81 - 2.04)

 

CC

47/38

1.0 (reference)

6/21

0.24 (0.09 - 0.67) 0.006

0.19 0.22

17/10

1.49 (0.56 - 3.95)

 

PER2

        

rs11695472

        

AA

173/187

1.0 (reference)

68/87

0.87 (0.59 - 1.29)

 

63/48

1.37 (0.88 - 2.14)

 

AC

117/143

0.90 (0.65 - 1.25)

38/54

0.74 (0.47 - 1.16)

 

36/44

0.87 (0.54 - 1.39)

 

CC

22/21

1.24 (0.64 - 2.39)

16/7

2.69 (1.08 - 6.73) 0.03

0.28 0.25

9/8

1.32 (0.48 - 3.65)

 
    

Ptrendf = 0.93

  

Ptrendf = 0.79

 

AA

173/187

1.0 (reference)

68/87

0.87 (0.59 - 1.29)

 

63/48

1.37 (0.88 - 2.14)

 

AC

117/143

1.0 (reference)

38/54

0.83 (0.50 - 1.39)

 

36/44

0.93 (0.55 - 1.55)

 

CC

22/21

1.0 (reference)

16/7

1.91 (0.59 - 6.22)

 

9/8

0.83 (0.22 - 3.14)

 

PER3

        

rs1012477

        

GG

203/237

1.0 (reference)

88/97

1.12 (0.77 - 1.58)

 

66/73

1.02 (0.69 - 1.51)

 

GC

95/100

1.10 (0.78 - 1.56)

22/51

0.42 (0.24 - 0.72) 0.002

0.02 0.08

35/24

1.56 (0.91 - 2.68)

 

CC

9/7

1.69 (0.58 - 4.93)

3/1

3.42 (0.35 - 33.40)

 

3/2

1.90 (0.31 - 11.58)

 
    

Ptrendf = 0.15

  

Ptrendf = 0.08

 

GG

203/237

1.0 (reference)

88/97

1.12 (0.77 - 1.58)

 

66/73

1.02 (0.69 - 1.51)

 

GC

95/100

1.0 (reference)

22/51

0.38 (0.18 - 0.66) 0.001

0.01 0.06

35/24

1.46 (0.79 - 2.72)

 

CC

9/7

1.0 (reference)

3/1

3.00 (0.12 - 77.00)

 

3/2

1.30 (0.06 - 28.93)

 

ROR-b

        

rs3903529

        

TT

162/183

1.0 (reference)

64/70

1.09 (0.71 - 1.66)

 

51/47

1.20 (0.75 - 1.93)

 

TA

123/131

1.08 (0.77 - 1.51)

41/62

0.75 (0.49 - 1.15)

 

40/47

0.92 (0.59 - 1.46)

 

AA

22/27

0.98 (0.53 - 1.82)

13/18

0.76 (0.36 - 1.59)

 

14/5

2.77 (0.98 - 7.86) 0.056

0.38 0.27

    

Ptrendf = 0.26

  

Ptrendf = 0.21

 

TT

162/183

1.0 (reference)

64/70

1.09 (0.71 - 1.66)

 

51/47

1.20 (0.75 - 1.93)

 

TA

123/131

1.0 (reference)

41/62

0.72 (0.44 - 1.16)

 

40/47

0.94 (0.57 - 1.55)

 

AA

22/27

1.0 (reference)

13/18

0.78 (0.30 - 2.05)

 

14/5

3.07 (0.84 - 11.18)

 

rs7022435

        

GG

178/194

1.0 (reference)

72/85

0.97 (0.65 - 1.43)

 

55/56

1.05 (0.67 - 1.64)

 

GA

115/128

1.00 (0.72 - 1.40)

44/49

1.02 (0.65 - 1.60)

 

41/32

1.38 (0.84 - 2.26)

 

AA

15/19

0.93 (0.45 - 1.90)

3/12

0.25 (0.07 - 0.89) 0.03

0.41 0.27

11/8

1.34 (0.52 - 3.41)

 
    

Ptrendf = 0.25

  

Ptrendf = 0.15

 

GG

178/194

1.0 (reference)

72/85

0.97 (0.65 - 1.43)

 

55/56

1.05 (0.67 - 1.64)

 

GA

115/128

1.0 (reference)

44/49

1.03 (0.62 - 1.70)

 

41/32

1.34 (0.78 - 2.92)

 

AA

15/19

1.0 (reference)

3/12

0.29 (0.06 - 1.33)

 

11/8

2.18 (0.55 - 8.61)

 

rs3750420

        

CC

136/166

1.0 (reference)

52/66

0.99 (0.63 - 1.55)

 

41/47

1.02 (0.61 - 1.68)

 

CT

136/143

1.20 (0.86 - 1.68)

60/58

1.24 (0.83 - 1.86)

 

48/35

1.60 (1.00 - 2.56) 0.05

0.15 0.20

TT

28/31

1.18 (0.67 - 2.08)

6/18

0.37 (0.14 - 0.96) 0.04

0.31 0.25

17/12

1.52 (0.71 - 3.28)

 
    

Ptrendf = 0.82

  

P trend f = 0.03

 

CC

136/166

1.0 (reference)

52/66

0.99 (0.63 - 1.55)

 

41/47

1.02 (0.61 - 1.68)

 

CT

136/143

1.0 (reference)

60/58

1.13 (0.72 - 1.77)

 

48/35

1.47 (0.88 - 2.45)

 

TT

28/31

1.0 (reference)

6/18

0.33 (0.11 - 1.00) 0.05

0.39 0.27

17/12

1.39 (0.54 - 3.60)

 

MTNR1A

        

rs13113549

        

TT

113/109

1.0 (reference)

48/54

0.94 (0.57 - 1.53)

 

35/33

1.09 (0.62 - 1.93)

 

TC

142/155

0.94 (0.66 - 1.35)

59/60

1.08 (0.72 - 1.61)

 

52/49

1.08 (0.71 - 1.65)

 

CC

55/75

0.75 (0.48 - 1.18)

16/34

0.47 (0.25 - 0.91) 0.02

0.15 0.20

22/18

1.24 (0.65 - 2.39)

 
    

Ptrendf = 0.08

  

Ptrendf = 0.71

 

TT

113/109

1.0 (reference)

48/54

0.94 (0.57 - 1.53)

 

35/33

1.09 (0.62 - 1.93)

 

TC

142/155

1.0 (reference)

59/60

1.03 (0.66 - 1.61)

 

52/49

1.09 (0.68 - 1.75)

 

CC

55/75

1.0 (reference)

16/34

0.57 (0.27 - 0.19)

 

22/18

1.28 (0.61 - 2.68)

 

MTNR1B

        

rs10830963

        

CC

176/195

1.0 (reference)

63/84

0.83 (0.58 - 1.23)

 

51/50

1.01 (0.64 - 1.61)

 

CG

105/123

0.86 (0.61 - 1.21)

46/51

1.06 (0.69 - 1.64)

 

46/45

1.13 (0.73 - 1.75)

 

GG

21/21

1.05 (0.55 - 2.02)

11/7

1.59 (0.59 - 4.25)

 

9/1

9.12 (1.14 - 73.09) 0.04

0.59 0.29

    

Ptrendf = 0.76

  

Ptrendf = 0.10

 

CC

176/195

1.0 (reference)

63/84

0.83 (0.58 - 1.23)

 

51/50

1.01 (0.64 - 1.61)

 

CG

105/123

1.0 (reference)

46/51

1.17 (0.71 - 1.93)

 

46/45

1.26 (0.76 - 2.08)

 

GG

21/21

1.0 (reference)

11/7

1.44 (0.43 - 4.86)

 

9/1

9.45 (0.97 - 91.82)

 
  1. aNumber of cases and controls that were successfully genotyped. bOR derived from unconditional logistic regression, including an interaction term between the night shift variable and the SNP genotypes, and adjusted for age at diagnosis (cases) or interview (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family members (mother or sister). cP interaction was obtained from the interaction term between the SNP genotypes and the night shift variable using frequency of the common genotype in the 0 to 2 night shift group as reference. Only significant or near-significant values are shown. dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see the Methods section. fPtrend values for Cochran-Armitage trend test were calculated from 2×C tables using frequency of genotypes in cases and controls from 0 to 2 night shift group as reference.
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