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Table 5 Odds ratios and 95% confidence intervals comparing odds of breast cancer associated with each polymorphism among women with less than two consecutive night shifts for 5 or more years compared to women with three consecutive night shifts or women with four or more consecutive night shifts for 5 or more years

From: Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts

Genes and SNPs Number of consecutive night shifts nurse has ever worked for 5 or more years
  0 to 2 consecutive nights 3 consecutive nights 4 or more consecutive nights
  Caa/Coa OR (95% CI)b Caa/Coa OR (95% CI)b Pinterc FPRPd BFDPe Caa/Coa OR (95% CI)b Pinterc FPRPd BFDPe
ARNTL1/ BMAL1         
rs2290035         
TT 106/121 1.0 (reference) 40/46 0.98 (0.58 - 1.65)   26/26 0.99 (0.53 - 1.88)  
TA 149/161 1.03 (0.72 - 1.47) 66/71 1.04 (0.71 - 1.51)   46/50 1.02 (0.66 - 1.57)  
AA 50/61 0.95 (0.59 - 1.52) 16/27 0.69 (0.36 - 1.34)   36/21 1.91 (1.08 - 3.37) 0.03 0.12 0.19
     Ptrendf = 0.60    Ptrendf = 0.08  
TT 106/121 1.0 (reference) 40/46 0.98 (0.58 - 1.65)   26/26 0.99 (0.53 - 1.88)  
TA 149/161 1.0 (reference) 66/71 0.99 (0.65 - 1.50)   46/50 1.10 (0.64 - 1.63)  
AA 50/61 1.0 (reference) 16/27 0.75 (0.35 - 1.60)   36/21 1.95 (0.97 - 3.90) 0.06 0.25 0.24
rs2278749         
CC 212/231 1.0 (reference) 97/92 1.19 (0.84 - 1.70)   66/58 1.26 (0.83 - 1.91)  
CT 86/87 1.19 (0.83 - 1.73) 22/45 0.51 (0.29 - 0.87) 0.01 0.07 0.15 33/32 1.10 (0.64 - 1.84)  
TT 7/19 0.40 (0.16 - 0.98) 1/5 0.26 (0.03 - 2.38)   5/6 0.84 (0.25 - 2.82)  
     Ptrendf = 0.07    Ptrendf = 0.52  
CC 212/231 1.0 (reference) 97/92 1.19 (0.84 - 1.70)   66/58 1.26 (0.83 - 1.91)  
CT 86/87 1.0 (reference) 22/45 0.47 (0.25 - 0.88) 0.02 0.12 0.18 33/32 0.99 (0.55 - 1.79)  
TT 7/19 1.0 (reference) 1/5 1.33 (0.10 - 17.78)   5/6 2.68 (0.48 - 15.01)  
rs969485         
AA 161/189 1.0 (reference) 51/74 0.83 (0.54 - 1.28)   41/50 0.92 (0.57 - 1.49)  
AG 105/117 1.05 (0.74 - 1.49) 58/55 1.23 (0.82 - 1.85)   50/35 1.64 (1.03 - 2.61) 0.04 0.12 0.18
GG 21/20 1.07 (0.54 - 2.09) 8/8 1.40 (0.50 - 3.94)   9/7 1.50 (0.53 - 4.22)  
     Ptrendf = 0.49    P trend f = 0.05  
AA 161/189 1.0 (reference) 51/74 0.83 (0.54 - 1.28)   41/50 0.92 (0.57 to 1.49)  
AG 105/117 1.0 (reference) 58/55 1.50 (0.72 - 1.85)   50/35 1.63 (0.96 - 2.76) 0.07 0.21 0.23
GG 21/20 1.0 (reference) 8/8 1.35 (0. 37 - 4.88)   9/7 1.60 (0.38 - 6.74)  
ARNTL2/ BMAL2         
rs2306074         
TT 143/144 1.0 (reference) 58/63 0.91 (0.59 - 1.43)   51/53 0.97 (0.61 - 1.53)  
TC 134/163 0.84 (0.60 - 1.17) 60/68 0.97 (0.66 - 1.42)   50/40 1.36 (0.86 - 2.13)  
CC 37/39 1.04 (0.61 - 1.76) 6/21 0.30 (0.17 - 0.75) 0.01 0.18 0.21 9/9 1.03 (0.39 - 2.72)  
     Ptrendf = 0.06    Ptrendf = 0.51  
TT 143/144 1.0 (reference) 58/63 0.91 (0.59 - 1.43)   51/53 0.97 (0.61 - 1.53)  
TC 134/163 1.0 (reference) 60/68 1.06 (0.68 - 1.64)   50/40 1.37 (0.83 - 2.26)  
CC 37/39 1.0 (reference) 6/21 0.24 (0.08 - 0.77) 0.02 0.31 0.25 9/9 0.99 (0.32 - 3.11)  
CLOCK         
rs3749474         
CC 123/131 1.0 (reference) 52/55 0.97 (0.68 - 1.37)   48/42 1.08 (0.73 - 1.59)  
CT 148/152 1.04 (0.74 - 1.47) 56/63 0.87 (0.46 - 1.63)   47/45 1.84 (0.92 - 3.69)  
TT 39/66 0.60 (0.37 - 0.97) 16/29 0.24 (0.05 - 1.18) 0.07 0.56 0.29 13/13 3.15 (0.62 - 16.14)  
     Ptrendf = 0.24    Ptrendf = 0.63  
CC 123/131 1.0 (reference) 52/55 0.97 (0.68 - 1.37)   48/42 1.08 (0.73 - 1.59)  
CT 148/152 1.0 (reference) 56/63 0.64 (0.30 - 1.36)   47/45 1.44 (0.63 - 3.31)  
TT 39/66 1.0 (reference) 16/29 0.30 (0.05 - 1.77)   13/13 2.12 (0.30 - 15.15)  
CSNK1E         
rs1534891         
GG 241/258 1.0 (reference) 98/112 0.93 (0.66 - 1.309)   82/76 1.12 80.77 - 1.62)  
GA 62/77 0.83 (0.57 - 1.23) 17/35 0.55 (0.30 - 1.01) 0.05 0.21 0.23 25/25 1.09 (0.61 - 1.95)  
AA 5/9 0.51 (0.16 - 1.60) 2/1 2.00 (0.17 - 23.92)   1/2 0.39 (0.03 - 4.68)  
     Ptrendf = 0.13    Ptrendf = 0.66  
GG 241/258 1.0 (reference) 98/112 0.93 (0.66 - 1.309)   82/76 1.12 80.77 - 1.62)  
GA 62/77 1.0 (reference) 17/35 0.63 (0.31 - 1.28)   25/25 1.11 (0.56 - 2.21)  
AA 5/9 1.0 (reference) 2/1 2.58 (0.14 - 91.16)   1/2 2.84 (0.08 - 96.47)  
rs5757037         
CC 126/154 1.0 (reference) 49/57 1.10 (0.68 - 1.76)   41/38 1.28 (0.75 - 2.70)  
CT 137/140 1.11 (0.79 - 1.58) 51/77 0.67 (0.45 - 0.99) 0.05 0.13 0.18 49/45 1.14 (0.74 - 1.77)  
TT 43/43 1.04 (0.63 - 1.71) 14/16 0.90 (0.43 - 1.90)   16/16 1.00 (0.49 - 2.05)  
     Ptrendf = 0.57    Ptrendf = 0.22  
CC 126/154 1.0 (reference) 49/57 1.10 (0.68 - 1.76)   41/38 1.28 (0.75 - 2.70)  
CT 137/140 1.0 (reference) 51/77 0.65 (0.42 - 1.02)   49/45 1.08 (0.66 - 1.75)  
TT 43/43 1.04 (0.63- 1.71) 14/16 0.89 (0.38 - 2.10)   16/16 0.97 (0.42 - 2.23)  
NPAS2         
rs2305160         
GG 136/134 1.0 (reference) 52/57 0.86 (0.54 - 1.36)   50/42 1.15 (0.70 - 1.88)  
GA 130/151 0.84 (0.59 - 1.18) 51/69 0.84 (0.56 - 1.25)   43/41 1.10 (0.70 - 1.74)  
AA 41/56 0.72 (0.45 - 1.18) 18/21 0.87 (0.45 - 1.69)   14/13 1.22 (0.56 - 2.64)  
     Ptrendf = 0.21    Ptrendf = 0.79  
rs2305160         
GG 136/134 1.0 (reference) 52/57 0.86 (0.54 - 1.36)   50/42 1.15 (0.70 - 1.88)  
GA 130/151 1.0 (reference) 51/69 0.95 (0.61 - 1.50)   43/41 1.19 (0.72 - 1.96)  
AA 41/56 1.0 (reference) 18/21 1.10 (0.50 - 2.40)   14/13 1.43 (0.58 - 3.52)  
rs17024926         
TT 110/133 1.0 (reference) 60/66 1.22 (0.78 - 1.92)   36/45 1.03 (0.61 - 1.75)  
TC 148/178 1.08 (0.76 - 1.52) 55/64 0.98 (0.66 - 1.47)   54/46 1.23 (0.80 - 1.89)  
CC 47/38 1.51 (0.90 - 2.52) 6/21 0.33 (0.13 - 0.84) 0.020 0.24 0.23 17/10 1.89 (0.85 - 4.23)  
     Ptrendf = 0.28    P trend f = 0.05  
TT 110/133 1.0 (reference) 60/66 1.22 (0.78 - 1.92)   36/45 1.03 (0.61 - 1.75)  
TC 148/178 1.0 (reference) 55/64 1.01 (0.65 - 1.57)   54/46 1.28 (0.81 - 2.04)  
CC 47/38 1.0 (reference) 6/21 0.24 (0.09 - 0.67) 0.006 0.19 0.22 17/10 1.49 (0.56 - 3.95)  
PER2         
rs11695472         
AA 173/187 1.0 (reference) 68/87 0.87 (0.59 - 1.29)   63/48 1.37 (0.88 - 2.14)  
AC 117/143 0.90 (0.65 - 1.25) 38/54 0.74 (0.47 - 1.16)   36/44 0.87 (0.54 - 1.39)  
CC 22/21 1.24 (0.64 - 2.39) 16/7 2.69 (1.08 - 6.73) 0.03 0.28 0.25 9/8 1.32 (0.48 - 3.65)  
     Ptrendf = 0.93    Ptrendf = 0.79  
AA 173/187 1.0 (reference) 68/87 0.87 (0.59 - 1.29)   63/48 1.37 (0.88 - 2.14)  
AC 117/143 1.0 (reference) 38/54 0.83 (0.50 - 1.39)   36/44 0.93 (0.55 - 1.55)  
CC 22/21 1.0 (reference) 16/7 1.91 (0.59 - 6.22)   9/8 0.83 (0.22 - 3.14)  
PER3         
rs1012477         
GG 203/237 1.0 (reference) 88/97 1.12 (0.77 - 1.58)   66/73 1.02 (0.69 - 1.51)  
GC 95/100 1.10 (0.78 - 1.56) 22/51 0.42 (0.24 - 0.72) 0.002 0.02 0.08 35/24 1.56 (0.91 - 2.68)  
CC 9/7 1.69 (0.58 - 4.93) 3/1 3.42 (0.35 - 33.40)   3/2 1.90 (0.31 - 11.58)  
     Ptrendf = 0.15    Ptrendf = 0.08  
GG 203/237 1.0 (reference) 88/97 1.12 (0.77 - 1.58)   66/73 1.02 (0.69 - 1.51)  
GC 95/100 1.0 (reference) 22/51 0.38 (0.18 - 0.66) 0.001 0.01 0.06 35/24 1.46 (0.79 - 2.72)  
CC 9/7 1.0 (reference) 3/1 3.00 (0.12 - 77.00)   3/2 1.30 (0.06 - 28.93)  
ROR-b         
rs3903529         
TT 162/183 1.0 (reference) 64/70 1.09 (0.71 - 1.66)   51/47 1.20 (0.75 - 1.93)  
TA 123/131 1.08 (0.77 - 1.51) 41/62 0.75 (0.49 - 1.15)   40/47 0.92 (0.59 - 1.46)  
AA 22/27 0.98 (0.53 - 1.82) 13/18 0.76 (0.36 - 1.59)   14/5 2.77 (0.98 - 7.86) 0.056 0.38 0.27
     Ptrendf = 0.26    Ptrendf = 0.21  
TT 162/183 1.0 (reference) 64/70 1.09 (0.71 - 1.66)   51/47 1.20 (0.75 - 1.93)  
TA 123/131 1.0 (reference) 41/62 0.72 (0.44 - 1.16)   40/47 0.94 (0.57 - 1.55)  
AA 22/27 1.0 (reference) 13/18 0.78 (0.30 - 2.05)   14/5 3.07 (0.84 - 11.18)  
rs7022435         
GG 178/194 1.0 (reference) 72/85 0.97 (0.65 - 1.43)   55/56 1.05 (0.67 - 1.64)  
GA 115/128 1.00 (0.72 - 1.40) 44/49 1.02 (0.65 - 1.60)   41/32 1.38 (0.84 - 2.26)  
AA 15/19 0.93 (0.45 - 1.90) 3/12 0.25 (0.07 - 0.89) 0.03 0.41 0.27 11/8 1.34 (0.52 - 3.41)  
     Ptrendf = 0.25    Ptrendf = 0.15  
GG 178/194 1.0 (reference) 72/85 0.97 (0.65 - 1.43)   55/56 1.05 (0.67 - 1.64)  
GA 115/128 1.0 (reference) 44/49 1.03 (0.62 - 1.70)   41/32 1.34 (0.78 - 2.92)  
AA 15/19 1.0 (reference) 3/12 0.29 (0.06 - 1.33)   11/8 2.18 (0.55 - 8.61)  
rs3750420         
CC 136/166 1.0 (reference) 52/66 0.99 (0.63 - 1.55)   41/47 1.02 (0.61 - 1.68)  
CT 136/143 1.20 (0.86 - 1.68) 60/58 1.24 (0.83 - 1.86)   48/35 1.60 (1.00 - 2.56) 0.05 0.15 0.20
TT 28/31 1.18 (0.67 - 2.08) 6/18 0.37 (0.14 - 0.96) 0.04 0.31 0.25 17/12 1.52 (0.71 - 3.28)  
     Ptrendf = 0.82    P trend f = 0.03  
CC 136/166 1.0 (reference) 52/66 0.99 (0.63 - 1.55)   41/47 1.02 (0.61 - 1.68)  
CT 136/143 1.0 (reference) 60/58 1.13 (0.72 - 1.77)   48/35 1.47 (0.88 - 2.45)  
TT 28/31 1.0 (reference) 6/18 0.33 (0.11 - 1.00) 0.05 0.39 0.27 17/12 1.39 (0.54 - 3.60)  
MTNR1A         
rs13113549         
TT 113/109 1.0 (reference) 48/54 0.94 (0.57 - 1.53)   35/33 1.09 (0.62 - 1.93)  
TC 142/155 0.94 (0.66 - 1.35) 59/60 1.08 (0.72 - 1.61)   52/49 1.08 (0.71 - 1.65)  
CC 55/75 0.75 (0.48 - 1.18) 16/34 0.47 (0.25 - 0.91) 0.02 0.15 0.20 22/18 1.24 (0.65 - 2.39)  
     Ptrendf = 0.08    Ptrendf = 0.71  
TT 113/109 1.0 (reference) 48/54 0.94 (0.57 - 1.53)   35/33 1.09 (0.62 - 1.93)  
TC 142/155 1.0 (reference) 59/60 1.03 (0.66 - 1.61)   52/49 1.09 (0.68 - 1.75)  
CC 55/75 1.0 (reference) 16/34 0.57 (0.27 - 0.19)   22/18 1.28 (0.61 - 2.68)  
MTNR1B         
rs10830963         
CC 176/195 1.0 (reference) 63/84 0.83 (0.58 - 1.23)   51/50 1.01 (0.64 - 1.61)  
CG 105/123 0.86 (0.61 - 1.21) 46/51 1.06 (0.69 - 1.64)   46/45 1.13 (0.73 - 1.75)  
GG 21/21 1.05 (0.55 - 2.02) 11/7 1.59 (0.59 - 4.25)   9/1 9.12 (1.14 - 73.09) 0.04 0.59 0.29
     Ptrendf = 0.76    Ptrendf = 0.10  
CC 176/195 1.0 (reference) 63/84 0.83 (0.58 - 1.23)   51/50 1.01 (0.64 - 1.61)  
CG 105/123 1.0 (reference) 46/51 1.17 (0.71 - 1.93)   46/45 1.26 (0.76 - 2.08)  
GG 21/21 1.0 (reference) 11/7 1.44 (0.43 - 4.86)   9/1 9.45 (0.97 - 91.82)  
  1. aNumber of cases and controls that were successfully genotyped. bOR derived from unconditional logistic regression, including an interaction term between the night shift variable and the SNP genotypes, and adjusted for age at diagnosis (cases) or interview (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family members (mother or sister). cP interaction was obtained from the interaction term between the SNP genotypes and the night shift variable using frequency of the common genotype in the 0 to 2 night shift group as reference. Only significant or near-significant values are shown. dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see the Methods section. fPtrend values for Cochran-Armitage trend test were calculated from 2×C tables using frequency of genotypes in cases and controls from 0 to 2 night shift group as reference.