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Table 4 Odds ratios and 95% confidence intervals comparing odds of breast cancer associated with each polymorphism among women with less than two consecutive night shifts compared to women with three consecutive night shifts or women with four or more consecutive night shifts.

From: Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts

Genes and SNPs

Number of consecutive night shifts that nurse has worked in all jobs

 

0 to 2 consecutive night shifts

Three consecutive night shifts

≥4 consecutive night shifts

 

Caa/Coa

OR (95% CI)b

Caa/Coa

OR (95% CI)b Pinterc

FPRPd BFDPe

Caa/Coa

OR (95% CI)b P inter c

FPRPd BFDPe

CLOCK

        

rs11133373

        

CC

72/77

1.0 (reference)

71/68

0.82 (0.52 - 1.30)

 

103/99

1.29 (0.79 - 2.11)

 

CG

76/72

0.98 (0.61 -1.57)

58/82

0.77 (0.53 - 1.13)

 

93/114

0.87 (0.63 - 1.20)

 

GG

14/25

1.05 (0.49 - 2.29)

13/29

0.50 (0.25 - 0.99) 0.05

0.22 0.23

28/23

1.17 (0.65 - 2.10)

 
    

P trend f = 0.04

  

Ptrendf = 0.95

 

CC

72/77

1.0 (reference)

71/68

0.82 (0.52 - 1.30)

 

103/99

1.29 (0.79 - 2.11)

 

CG

76/72

1.0 (reference)

58/82

0.88 (0.56 - 1.39)

 

93/114

0.79 (0.48 - 1.30)

 

GG

14/25

1.0 (reference)

13/29

0.83 (0.34 - 2.04)

 

28/23

2.75 (1.07 - 7.09) 0.04

0.30 0.25

rs3749474

        

CC

67/71

1.0 (reference)

60/66

0.95 (0.57 - 1.57)

 

96/91

1.14 (0.72 - 1.80)

 

CT

77/76

1.12 (0.69-1.81)

73/78

1.01 (0.70 - 1.46)

 

101/106

1.03 (0.74 - 1.42)

 

TT

16/30

0.55 (0.27-1.14)

20/37

0.56 (0.31 - 0.99) 0.05

0.18 0.21

32/41

0.85 (0.52 - 1.39)

 
    

Ptrendf = 0.30

  

Ptrendf = 0.54

 

CC

67/71

1.0 (reference)

60/66

0.95 (0.57 - 1.57)

 

96/91

1.14 (0.72 - 1.80)

 

CT

77/76

1.0 (reference)

73/78

0.93 (0.58 - 1.48)

 

101/106

0.98 (0.63 - 1.51)

 

TT

16/30

1.0 (reference)

20/37

1.10 (0.46 - 2.61)

 

32/41

1.35 (0.61 - 3.00)

 

CRY2

        

rs11038689

        

AA

87/97

1.0 (reference)

84/97

0.99 (0.67 - 1.47)

 

127/127

1.36 (0.87 - 2.13)

 

AG

52/55

1.10 (0.66 - 1.81)

45/57

0.82 (0.54 - 1.26)

 

68/70

0.94 (0.65 - 1.37)

 

GG

8/11

0.86 (0.32 - 2.28)

13/12

1.11 (0.49 - 2.51)

 

7/20

0.42 (0.17 - 1.01) 0.05

0.31 0.25

    

Ptrendf = 0.91

  

Ptrendf = 0.39

 

AA

87/97

1.0 (reference)

84/97

0.99 (0.67 - 1.47)

 

127/127

1.36 (0.87 - 2.13)

 

AG

52/55

1.0 (reference)

45/57

0.98 (0.58 - 1.68)

 

68/70

0.82 (0.46 - 1.47)

 

GG

8/11

1.0 (reference)

13/12

0.44 (0.09 - 2.06)

 

7/20

1.44 (0.33 - 6.20)

 

rs1401417

        

CC

78/94

1.0 (reference)

75/95

1.01 (0.65 - 1.58)

 

119/120

1.27 (0.84 - 1.91)

 

CG

46/54

1.10 (0.65-1.86)

40/56

0.76 (0.49 - 1.18)

 

72/68

1.13 (0.77 - 1.64)

 

GG

8/8

1.36 (0.47-3.94)

10/13

0.86 (0.37 - 2.01)

 

4/17

0.31 (0.10 - 0.94) 0.04

0.37 0.26

    

Ptrendf = 0.61

  

Ptrendf = 0.78

 

CC

78/94

1.0 (reference)

75/95

1.01 (0.65 - 1.58)

 

119/120

1.27 (0.84 - 1.91)

 

CG

46/54

1.0 (reference)

40/56

0.76 (0.42 - 1.37)

 

72/68

1.11 (0.65 - 1.90)

 

GG

8/8

1.0 (reference)

10/13

0.22 (0.18 to 3.74)

 

4/17

0.25 (0.05 to 1.37)

 

NPAS2

        

rs2305160

        

GG

75/72

1.0 (reference)

58/71

0.78 (0.48 - 1.28)

 

105/90

1.16 (0.74 - 1.81)

 

GA

61/74

0.82 (0.50 - 1.33)

69/83

0.87 (0.60 - 1.25)

 

94/104

0.93 (0.67 - 1.29)

 

AA

25/27

0.89 (0.46 - 1.72)

21/28

0.73 (0.40 - 1.34)

 

27/35

0.87 (0.51 - 1.50)

 
    

Ptrendf = 0.26

  

Ptrendf = 0.21

 

GG

75/72

1.0 (reference)

58/71

0.78 (0.48 - 1.28)

 

105/90

1.16 (0.74 - 1.81)

 

GA

61/74

1.0 (reference)

69/83

1.06 (0.65 - 1.73)

 

94/104

1.12 (0.71 - 1.76)

 

AA

25/27

1.0 (reference)

21/28

0.76 (0.33 - 1.72)

 

27/35

0.86 (0.39 - 1.92)

 

ROR-b

        

rs3903529

        

TT

76/100

1.0 (reference)

81/89

1.29 (0.82 - 2.01)

 

120/111

1.41 (0.93 - 2.14)

 

TA

72/58

1.67 (1.03 - 2.70)

51/73

0.74 (0.49 - 1.10)

 

81/109

0.81 (0.58 - 1.13)

 

AA

10/16

0.89 (0.37 - 2.15)

12/19

0.61 (0.29 - 1.31)

 

27/15

1.87 (1.00 - 3.61) 0.06

0.24 0.24

    

Ptrendf = 0.60

  

Ptrendf = 0.28

 

TT

76/100

1.0 (reference)

81/89

1.29 (0.82 - 2.01)

 

120/111

1.41 (0.93 - 2.14)

 

TA

72/58

1.0 (reference)

51/73

0.57 (0.34 - 0.95) 0.03

0.12 0.18

81/109

0.66 (0.41 - 1.05)

 

AA

10/16

1.0 (reference)

12/19

0.91 (0.30 - 2.80)

 

27/15

2.47 (0.83 - 7.34)

P trend = 0.03

 

rs7022435

        

GG

89/100

1.0 (reference)

92/101

1.06 (0.69 - 1.62)

 

124/134

1.06 (0.71 - 1.57)

 

GA

65/62

1.21 (0.75 -1.93)

53/63

0.93 (0.61 - 1.40)

 

82/84

1.05 (0.75 - 1.49)

 

AA

8/9

1.12 (0.41 - 3.06)

3/18

0.16 (0.05 - 0.55) 0.004

0.24 0.23

18/12

1.55 (0.73 - 3.30)

 
    

Ptrendf = 0.21

  

Ptrendf = 0.31

 

rs7022435

        

GG

89/100

1.0 (reference)

92/101

1.06 (0.69 - 1.62)

 

124/134

1.06 (0.71 - 1.57)

 

GA

65/62

1.0 (reference)

53/63

0.81 (0.48 - 1.37)

 

82/84

0.93 (0.58 - 1.49)

 

AA

8/9

1.0 (reference)

3/18

0.17 (0.03 - 0.84) 0.03

0.49 0.28

18/12

1.68 (0.44 - 6.33)

 

rs3750420

        

CC

68/87

1.0 (reference)

68/80

1.12 (0.70 - 1.81)

 

93/112

1.03 (0.66 - 1.61)

 

CT

76/72

1.35 (0.84 - 2.18)

68/72

1.11 (0.76 - 1.62)

 

100/92

1.32 (0.95 - 1.83)

 

TT

13/15

1.25 (0.54 - 2.87)

9/25

0.40 (0.18 - 0.88) 0.02

0.19 0.22

29/21

1.57 (0.87 - 2.83)

 
    

Ptrendf = 0.58

  

P trend f = 0.04

 

CC

68/87

1.0 (reference)

68/80

1.12 (0.70 - 1.81)

 

93/112

1-03 (0.66 - 1.61)

 

CT

76/72

1.0 (reference)

68/72

0.91 (0.56 - 1.48)

 

100/92

1.13 (0.72 - 1.76)

 

TT

13/15

1.0 (reference)

9/25

0.34 (0.11 - 1.05)

 

29/21

1.35 (0.51 - 3.58)

 

AANAT

        

rs3760138

        

TT

38/52

1.0 (reference)

42/57

0.93 (0.51 - 1.70)

 

69/72

1.19 (0.68 - 2.08)

 

TG

86/85

1.17 (0.68 - 2.00)

75/95

0.87 (0.61 - 1.24)

 

108/135

0.91 (0.67 - 1.24)

 

GG

40/42

1.18 (0.63 - 2.21)

33/32

1.23 (0.72 - 2.08)

 

55/32

1.82 (1.13 - 2.93) 0.01

0.06 0.14

    

P trend f = 0.03

  

P trend f = 0.04

 

TT

38/52

1.0 (reference)

42/57

0.93 (0.51 - 1.70)

 

69/72

1.19 (0.68 - 2.08)

 

TG

86/85

1.0 (reference)

75/95

0.80 (0.51 - 1.25)

 

108/135

0.82 (0.54 - 1.23)

 

GG

40/42

1.0 (reference)

33/32

1.28 (0.64 - 2.57)

 

55/32

1.84 (0.94 - 3.62)

 

rs4238989

        

GG

43/60

1.0 (reference)

50/59

1.13 (0.64 - 2.01)

 

68/84

1.07 (0.62 - 1.83)

 

GC

77/82

1.20 (0.72 - 2.02)

66/86

0.87 (0.60 - 1.27)

 

120/120

1.18 (0.87 - 1.61)

 

CC

40/35

1.47 (0.79 - 2.74)

37/39

1.15 (0.70 - 1.88)

 

43/30

1.62 (1.00 - 2.68) 0.06

0.19 0.22

    

Ptrendf = 0.49

  

P trend f = 0.02

 

GG

43/60

1.0 (reference)

50/59

1.13 (0.64 - 2.01)

 

68/84

1.07 (0.62 - 1.83)

 

GC

77/82

1.0 (reference)

66/86

0.85 (0.53 - 1.37)

 

120/120

1.11 (0.73 - 1.68)

 

CC

40/35

1.0 (reference)

37/39

1.02 (0.52 - 2.01)

 

43/30

1.40 (0.69 - 2.83)

 

MTNR1A

        

rs13113549

        

TT

51/60

1.0 (reference)

64/58

1.36 (0.79 - 2.34)

 

81/78

1.37 (0.82 - 2.27)

 

TC

84/88

1.19 (0.72-1.96)

67/80

0.89 (0.61 - 1.30)

 

102/96

1.08 (0.78 - 1.50)

 

CC

26/29

1.12 (0.57-2.20)

20/42

0.50 (0.28 - 0.90) 0.02

0.11 0.18

47/56

0.82 (0.54 - 1.26)

 
    

Ptrendf = 0.11

  

Ptrendf = 0.95

 

TT

51/60

1.0 (reference)

64/58

1.36 (0.79 - 2.34)

 

81/78

1.37 (0.82 - 2.27)

 

TC

84/88

1.0 (reference)

67/80

0.88 (0.55 - 1.40)

 

102/96

1.11 (0.73 - 1.71)

 

CC

26/29

1.0 (reference)

20/42

0.55 (0.25 - 1.23)

 

47/56

0.79 (0.40 - 1.59)

 

MTNR1B

        

rs10830963

        

CC

95/97

1.0 (reference)

76/103

0.74 (0.48 - 1.13)

 

119/129

0.90 (0.61 - 1.34)

 

CG

56/69

0.74 (0.46 - 1.19)

55/60

1.04 (0.69 - 1.56)

 

86/90

1.06 (0.76 - 1.49)

 

GG

7/8

0.76 (0.25 - 2.32)

15/13

1.29 (0.59 - 2.81)

 

19/8

2.48 (1.06 - 5.80) 0.04

0.26 0.24

    

Ptrendf = 0.99

  

Ptrendf = 0.35

 

CC

95/97

1.0 (reference)

76/103

0.74 (0.48 - 1.13)

 

119/129

0.90 (0.61 - 1.34)

 

CG

56/69

1.0 (reference)

55/60

1.18 (0.70 - 2.00)

 

86/90

1.23 (0.76 - 1.97)

 

GG

7/8

1.0 (reference)

15/13

1.55 (0.38 - 6.37)

 

19/8

3.51 (0.73 - 16.96)

 
  1. aNumber of cases and controls that were successfully genotyped. bOR derived from unconditional logistic regression, including an interaction term between the night shift variable and the SNP genotypes and adjusted for age at diagnosis (cases) or interview (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family members (mother or sister). cP interaction was obtained from the interaction term between the SNP genotypes and the night shift variable using frequency of the common genotype in the 0 to 2 night shift group as reference. Only significant or near-significant values are shown. dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see the Methods section. fPtrend values for Cochran-Armitage trend test were calculated from 2×C tables using frequency of genotypes in cases and controls from 0 to 2 night shift group as reference.
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Breast Cancer Research

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