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Table 4 Odds ratios and 95% confidence intervals comparing odds of breast cancer associated with each polymorphism among women with less than two consecutive night shifts compared to women with three consecutive night shifts or women with four or more consecutive night shifts.

From: Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts

Genes and SNPs Number of consecutive night shifts that nurse has worked in all jobs
  0 to 2 consecutive night shifts Three consecutive night shifts ≥4 consecutive night shifts
  Caa/Coa OR (95% CI)b Caa/Coa OR (95% CI)b Pinterc FPRPd BFDPe Caa/Coa OR (95% CI)b P inter c FPRPd BFDPe
CLOCK         
rs11133373         
CC 72/77 1.0 (reference) 71/68 0.82 (0.52 - 1.30)   103/99 1.29 (0.79 - 2.11)  
CG 76/72 0.98 (0.61 -1.57) 58/82 0.77 (0.53 - 1.13)   93/114 0.87 (0.63 - 1.20)  
GG 14/25 1.05 (0.49 - 2.29) 13/29 0.50 (0.25 - 0.99) 0.05 0.22 0.23 28/23 1.17 (0.65 - 2.10)  
     P trend f = 0.04    Ptrendf = 0.95  
CC 72/77 1.0 (reference) 71/68 0.82 (0.52 - 1.30)   103/99 1.29 (0.79 - 2.11)  
CG 76/72 1.0 (reference) 58/82 0.88 (0.56 - 1.39)   93/114 0.79 (0.48 - 1.30)  
GG 14/25 1.0 (reference) 13/29 0.83 (0.34 - 2.04)   28/23 2.75 (1.07 - 7.09) 0.04 0.30 0.25
rs3749474         
CC 67/71 1.0 (reference) 60/66 0.95 (0.57 - 1.57)   96/91 1.14 (0.72 - 1.80)  
CT 77/76 1.12 (0.69-1.81) 73/78 1.01 (0.70 - 1.46)   101/106 1.03 (0.74 - 1.42)  
TT 16/30 0.55 (0.27-1.14) 20/37 0.56 (0.31 - 0.99) 0.05 0.18 0.21 32/41 0.85 (0.52 - 1.39)  
     Ptrendf = 0.30    Ptrendf = 0.54  
CC 67/71 1.0 (reference) 60/66 0.95 (0.57 - 1.57)   96/91 1.14 (0.72 - 1.80)  
CT 77/76 1.0 (reference) 73/78 0.93 (0.58 - 1.48)   101/106 0.98 (0.63 - 1.51)  
TT 16/30 1.0 (reference) 20/37 1.10 (0.46 - 2.61)   32/41 1.35 (0.61 - 3.00)  
CRY2         
rs11038689         
AA 87/97 1.0 (reference) 84/97 0.99 (0.67 - 1.47)   127/127 1.36 (0.87 - 2.13)  
AG 52/55 1.10 (0.66 - 1.81) 45/57 0.82 (0.54 - 1.26)   68/70 0.94 (0.65 - 1.37)  
GG 8/11 0.86 (0.32 - 2.28) 13/12 1.11 (0.49 - 2.51)   7/20 0.42 (0.17 - 1.01) 0.05 0.31 0.25
     Ptrendf = 0.91    Ptrendf = 0.39  
AA 87/97 1.0 (reference) 84/97 0.99 (0.67 - 1.47)   127/127 1.36 (0.87 - 2.13)  
AG 52/55 1.0 (reference) 45/57 0.98 (0.58 - 1.68)   68/70 0.82 (0.46 - 1.47)  
GG 8/11 1.0 (reference) 13/12 0.44 (0.09 - 2.06)   7/20 1.44 (0.33 - 6.20)  
rs1401417         
CC 78/94 1.0 (reference) 75/95 1.01 (0.65 - 1.58)   119/120 1.27 (0.84 - 1.91)  
CG 46/54 1.10 (0.65-1.86) 40/56 0.76 (0.49 - 1.18)   72/68 1.13 (0.77 - 1.64)  
GG 8/8 1.36 (0.47-3.94) 10/13 0.86 (0.37 - 2.01)   4/17 0.31 (0.10 - 0.94) 0.04 0.37 0.26
     Ptrendf = 0.61    Ptrendf = 0.78  
CC 78/94 1.0 (reference) 75/95 1.01 (0.65 - 1.58)   119/120 1.27 (0.84 - 1.91)  
CG 46/54 1.0 (reference) 40/56 0.76 (0.42 - 1.37)   72/68 1.11 (0.65 - 1.90)  
GG 8/8 1.0 (reference) 10/13 0.22 (0.18 to 3.74)   4/17 0.25 (0.05 to 1.37)  
NPAS2         
rs2305160         
GG 75/72 1.0 (reference) 58/71 0.78 (0.48 - 1.28)   105/90 1.16 (0.74 - 1.81)  
GA 61/74 0.82 (0.50 - 1.33) 69/83 0.87 (0.60 - 1.25)   94/104 0.93 (0.67 - 1.29)  
AA 25/27 0.89 (0.46 - 1.72) 21/28 0.73 (0.40 - 1.34)   27/35 0.87 (0.51 - 1.50)  
     Ptrendf = 0.26    Ptrendf = 0.21  
GG 75/72 1.0 (reference) 58/71 0.78 (0.48 - 1.28)   105/90 1.16 (0.74 - 1.81)  
GA 61/74 1.0 (reference) 69/83 1.06 (0.65 - 1.73)   94/104 1.12 (0.71 - 1.76)  
AA 25/27 1.0 (reference) 21/28 0.76 (0.33 - 1.72)   27/35 0.86 (0.39 - 1.92)  
ROR-b         
rs3903529         
TT 76/100 1.0 (reference) 81/89 1.29 (0.82 - 2.01)   120/111 1.41 (0.93 - 2.14)  
TA 72/58 1.67 (1.03 - 2.70) 51/73 0.74 (0.49 - 1.10)   81/109 0.81 (0.58 - 1.13)  
AA 10/16 0.89 (0.37 - 2.15) 12/19 0.61 (0.29 - 1.31)   27/15 1.87 (1.00 - 3.61) 0.06 0.24 0.24
     Ptrendf = 0.60    Ptrendf = 0.28  
TT 76/100 1.0 (reference) 81/89 1.29 (0.82 - 2.01)   120/111 1.41 (0.93 - 2.14)  
TA 72/58 1.0 (reference) 51/73 0.57 (0.34 - 0.95) 0.03 0.12 0.18 81/109 0.66 (0.41 - 1.05)  
AA 10/16 1.0 (reference) 12/19 0.91 (0.30 - 2.80)   27/15 2.47 (0.83 - 7.34) P trend = 0.03  
rs7022435         
GG 89/100 1.0 (reference) 92/101 1.06 (0.69 - 1.62)   124/134 1.06 (0.71 - 1.57)  
GA 65/62 1.21 (0.75 -1.93) 53/63 0.93 (0.61 - 1.40)   82/84 1.05 (0.75 - 1.49)  
AA 8/9 1.12 (0.41 - 3.06) 3/18 0.16 (0.05 - 0.55) 0.004 0.24 0.23 18/12 1.55 (0.73 - 3.30)  
     Ptrendf = 0.21    Ptrendf = 0.31  
rs7022435         
GG 89/100 1.0 (reference) 92/101 1.06 (0.69 - 1.62)   124/134 1.06 (0.71 - 1.57)  
GA 65/62 1.0 (reference) 53/63 0.81 (0.48 - 1.37)   82/84 0.93 (0.58 - 1.49)  
AA 8/9 1.0 (reference) 3/18 0.17 (0.03 - 0.84) 0.03 0.49 0.28 18/12 1.68 (0.44 - 6.33)  
rs3750420         
CC 68/87 1.0 (reference) 68/80 1.12 (0.70 - 1.81)   93/112 1.03 (0.66 - 1.61)  
CT 76/72 1.35 (0.84 - 2.18) 68/72 1.11 (0.76 - 1.62)   100/92 1.32 (0.95 - 1.83)  
TT 13/15 1.25 (0.54 - 2.87) 9/25 0.40 (0.18 - 0.88) 0.02 0.19 0.22 29/21 1.57 (0.87 - 2.83)  
     Ptrendf = 0.58    P trend f = 0.04  
CC 68/87 1.0 (reference) 68/80 1.12 (0.70 - 1.81)   93/112 1-03 (0.66 - 1.61)  
CT 76/72 1.0 (reference) 68/72 0.91 (0.56 - 1.48)   100/92 1.13 (0.72 - 1.76)  
TT 13/15 1.0 (reference) 9/25 0.34 (0.11 - 1.05)   29/21 1.35 (0.51 - 3.58)  
AANAT         
rs3760138         
TT 38/52 1.0 (reference) 42/57 0.93 (0.51 - 1.70)   69/72 1.19 (0.68 - 2.08)  
TG 86/85 1.17 (0.68 - 2.00) 75/95 0.87 (0.61 - 1.24)   108/135 0.91 (0.67 - 1.24)  
GG 40/42 1.18 (0.63 - 2.21) 33/32 1.23 (0.72 - 2.08)   55/32 1.82 (1.13 - 2.93) 0.01 0.06 0.14
     P trend f = 0.03    P trend f = 0.04  
TT 38/52 1.0 (reference) 42/57 0.93 (0.51 - 1.70)   69/72 1.19 (0.68 - 2.08)  
TG 86/85 1.0 (reference) 75/95 0.80 (0.51 - 1.25)   108/135 0.82 (0.54 - 1.23)  
GG 40/42 1.0 (reference) 33/32 1.28 (0.64 - 2.57)   55/32 1.84 (0.94 - 3.62)  
rs4238989         
GG 43/60 1.0 (reference) 50/59 1.13 (0.64 - 2.01)   68/84 1.07 (0.62 - 1.83)  
GC 77/82 1.20 (0.72 - 2.02) 66/86 0.87 (0.60 - 1.27)   120/120 1.18 (0.87 - 1.61)  
CC 40/35 1.47 (0.79 - 2.74) 37/39 1.15 (0.70 - 1.88)   43/30 1.62 (1.00 - 2.68) 0.06 0.19 0.22
     Ptrendf = 0.49    P trend f = 0.02  
GG 43/60 1.0 (reference) 50/59 1.13 (0.64 - 2.01)   68/84 1.07 (0.62 - 1.83)  
GC 77/82 1.0 (reference) 66/86 0.85 (0.53 - 1.37)   120/120 1.11 (0.73 - 1.68)  
CC 40/35 1.0 (reference) 37/39 1.02 (0.52 - 2.01)   43/30 1.40 (0.69 - 2.83)  
MTNR1A         
rs13113549         
TT 51/60 1.0 (reference) 64/58 1.36 (0.79 - 2.34)   81/78 1.37 (0.82 - 2.27)  
TC 84/88 1.19 (0.72-1.96) 67/80 0.89 (0.61 - 1.30)   102/96 1.08 (0.78 - 1.50)  
CC 26/29 1.12 (0.57-2.20) 20/42 0.50 (0.28 - 0.90) 0.02 0.11 0.18 47/56 0.82 (0.54 - 1.26)  
     Ptrendf = 0.11    Ptrendf = 0.95  
TT 51/60 1.0 (reference) 64/58 1.36 (0.79 - 2.34)   81/78 1.37 (0.82 - 2.27)  
TC 84/88 1.0 (reference) 67/80 0.88 (0.55 - 1.40)   102/96 1.11 (0.73 - 1.71)  
CC 26/29 1.0 (reference) 20/42 0.55 (0.25 - 1.23)   47/56 0.79 (0.40 - 1.59)  
MTNR1B         
rs10830963         
CC 95/97 1.0 (reference) 76/103 0.74 (0.48 - 1.13)   119/129 0.90 (0.61 - 1.34)  
CG 56/69 0.74 (0.46 - 1.19) 55/60 1.04 (0.69 - 1.56)   86/90 1.06 (0.76 - 1.49)  
GG 7/8 0.76 (0.25 - 2.32) 15/13 1.29 (0.59 - 2.81)   19/8 2.48 (1.06 - 5.80) 0.04 0.26 0.24
     Ptrendf = 0.99    Ptrendf = 0.35  
CC 95/97 1.0 (reference) 76/103 0.74 (0.48 - 1.13)   119/129 0.90 (0.61 - 1.34)  
CG 56/69 1.0 (reference) 55/60 1.18 (0.70 - 2.00)   86/90 1.23 (0.76 - 1.97)  
GG 7/8 1.0 (reference) 15/13 1.55 (0.38 - 6.37)   19/8 3.51 (0.73 - 16.96)  
  1. aNumber of cases and controls that were successfully genotyped. bOR derived from unconditional logistic regression, including an interaction term between the night shift variable and the SNP genotypes and adjusted for age at diagnosis (cases) or interview (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family members (mother or sister). cP interaction was obtained from the interaction term between the SNP genotypes and the night shift variable using frequency of the common genotype in the 0 to 2 night shift group as reference. Only significant or near-significant values are shown. dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see the Methods section. fPtrend values for Cochran-Armitage trend test were calculated from 2×C tables using frequency of genotypes in cases and controls from 0 to 2 night shift group as reference.