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Table 3 Odds ratios and 95% confidence intervals for polymorphisms with statistically significant associations with risk of breast cancer.

From: Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts

Genes and SNPs Frequency of genotypesa OR (95% CI)b Pc FPRPd BFDPe
BMAL1 No. of cases No. of controls   
rs2278749     
CC 375 381 1.0  
CT 141 164 0.93 (0.70- 1.22)  
TT 13 30 0.45 (0.23- 0.90) 0.02 0.16 0.21
    Ptrend = 0.07  
CLOCK     
rs3749474     
CC 223 228 1.0  
CT 251 260 1.01 (0.78- 1.31)  
TT 68 108 0.64 (0.45- 0.92) 0.02 0.14 0.11
    P trend = 0.03  
AANAT     
rs3760138     
TT 149 181 1.0  
TG 269 315 1.00 (0.75- 1.32)  
GG 128 106 1.42 (1.01- 2.01) 0.05 0.13 0.18
    Ptrend = 0.07  
rs4238989     
GG 161 203 1.0  
GC 263 288 1.13 (0.86- 1.49)  
CC 120 104 1.43 (1.01- 2.01) 0.04 0.11 0.16
    Ptrend = 0.13  
  1. aNumber of cases and controls with successful genotyping data. bOdds ratios (ORs) derived from unconditional logistic regression and adjusted for age at diagnosis (cases) or day of reference (controls), selection period, alcohol use, hormone replacement therapy for the past 2 years, number of children and history of breast cancer in first-degree family (mother or sister). cPearson's χ2 test (two-sided) comparing frequency of the homozygote variant genotypes with homozygote common genotypes (reference). dThe false-positive report probability (FPRP) was calculated as described by Wacholder et al. [42]. FPRP < 0.2 was considered noteworthy. eThe Bayesian false-discovery probability (BFDP) was calculated as described by Wakefield et al. [41]. BFDP < 0.8 was considered noteworthy. For more details on FPRP and BFDP, see Methods section. Ptrend values for the Cochran-Armitage trend test were calculated from 2×C tables using frequency of cases and controls.