Table 1 Top fifteen over-represented gene ontology (GO) categories of liver × receptor ligand up- and downregulated genes
From: Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
GO biological processes | P-value |
|---|---|
Upregulated | |
Response to high density lipoprotein stimulus | 1.37E-06 |
Intracellular cholesterol transport | 4.57E-06 |
Cholesterol homeostasis | 6.55E-06 |
Negative regulation of cholesterol storage | 6.85E-06 |
Phospholipid homeostasis | 9.59E-06 |
Positive regulation of cholesterol efflux | 1.64E-05 |
Response to endoplasmic reticulum stress | 3.55E-05 |
Negative regulation of macrophage derived foam cell differentiation | 4.14E-05 |
Phospholipid efflux | 4.14E-05 |
Glutamine metabolic process | 7.77E-05 |
Reverse cholesterol transport | 7.77E-05 |
Positive regulation of protein catabolic process | 8.63E-05 |
Response to nutrient | 1.08E-04 |
Cholesterol efflux | 1.47E-04 |
Endoplasmic reticulum unfolded protein response | 1.59E-04 |
Downregulated | |
DNA replication | 1.66E-48 |
Cell cycle | 5.03E-21 |
DNA repair | 3.75E-18 |
Nucleotide-excision repair, DNA gap filling | 3.52E-13 |
DNA-dependent DNA replication initiation | 2.84E-12 |
Cell division | 1.09E-11 |
Mitosis | 1.41E-08 |
Response to DNA damage stimulus | 2.93E-08 |
Phosphoinositide-mediated signaling | 1.44E-06 |
DNA unwinding involved in replication | 3.23E-06 |
Modification-dependent protein catabolic process | 1.05E-05 |
Protein K6-linked ubiquitination | 1.99E-05 |
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 2.12E-05 |
DNA strand elongation involved in DNA replication | 4.95E-05 |
Response to organophosphorus | 4.95E-05 |