Figure 4
From: Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
Expression profiles of commonly upregulated liver × receptor ligand-responsive genes clustered breast cancer patients into two groups with similar disease outcomes. (A) Hierarchical clustering of 258 breast cancer patients by their expression profiles of 23 commonly upregulated genes defined two major patient groups. Kaplan-Meier analysis was carried out on two groups of patients defined by hierarchical clustering for (B) disease-free survival (DFS), (C) distant-metastasis-free survival (DMFS), and (D) disease-specific survival (DSS). Statistical significance of the differences between the two survival plots was determined by the log-rank test and indicated by the resulting P-value.