Figure 3From: Elevated expression of syntenin in breast cancer is correlated with lymph node metastasis and poor patient survivalSyntenin overexpression promotes breast tumor growth and lung metastasis in vivo. (A) Overexpression of syntenin promoted breast tumor growth in nude mice (P < 0.01). (B) Volumes of tumors formed by syntenin-knockdown cells were significantly smaller than control. Bars, SEM. Five mice in each group were used in this study. (C, D) Hematoxylin-eosin (HE) was used to examine the number of lung metastasis (200×). Quantification of average metastasis number of per lung (n = 5). (E, F) Immunohistochemistry examination of CD31 for microvessels in the final week of xenografts (200×). Quantification of average microvessel density per xenografts (n = 5). *P < 0.05.Back to article page