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Table 3 Hazard ratios comparing 5-year breast cancer-specific survival of women with interval cancers with women with screen-detected cancers, only including nondense breasts versus only including dense breasts

From: Mammographic density and survival in interval breast cancers

 

All

Nondense breasts

Dense breasts

Pvalue for interaction terma

 

HR

95% CI

Pvalue

HR

95% CI

Pvalue

HR

95% CI

Pvalue

 

Model 1b

3.50

2.25 to 5.44

<0.001

3.62

2.17 to 6.06

<0.001

3.00

1.26 to 7.17

0.013

0.742

Main model (model 2)c

2.17

1.36 to 3.47

0.001

2.43

1.44 to 4.10

0.001

1.41

0.53 to 3.74

0.486

0.304

Model 3d

1.69

1.03 to 2.76

0.038

1.76

1.01 to 3.09

0.047

1.26

0.47 to 3.38

0.649

0.337

  1. aTest of interaction between density and mode of detection (screen-detected cancer vs interval cancer). CI, confidence interval; HR, hazard ratio.
  2. bAdjusted for age, body mass index (BMI) and hormone replacement therapy (HRT) use.
  3. cAdjusted for age, BMI, HRT use and tumor size.
  4. dAdjusted for age, BMI, HRT use, tumor size and lymph node metastasis.