Table 3 Median change (interquartile range) of circulating biomarkers

IGF1 ng/mL

P

25

146

(117 to 177)

151

(105 to 205)

-0.5

(-14.5 to 12)

T vs. R

0.87

R

50

134.5

(113 to 174)

126

(104 to 157)

-10.1

(-30.4 to 13)

T + R vs. P

0.15

T

50

137.5

(113 to 170)

137

(92.7 to 168)

-13

(-27 to 11)

IGFBP-3 µg/mL

P

25

4.16

(3.75 to 4.76)

4.42

(3.79 to 4.84)

-0.09

(-0.29 to 0.22)

T vs. R

0.05

R

50

4.22

(3.84 to 4.71)

4.58

(4.07 to 5.11)

0.41

(0 to 0.69)

T + R vs. P

0.22

T

50

4.28

(3.72 to 4.73)

4.42

(3.87 to 4.78)

0.02

(-0.25 to 0.37)

IGF1/BP3 ratio

P

25

0.18

(0.16 to 0.21)

0.18

(0.15 to 0.24)

0

(-0.03 to 0.02)

T vs. R

0.41

R

50

0.17

(0.15 to 0.21)

0.16

(0.12 to 0.17)

-0.03

(-0.05 to 0)

T + R vs. P

0.01

T

50

0.18

(0.15 to 0.2)

0.17

(0.13 to 0.19)

-0.01

(-0.04 to 0)

SHBG nmol/L

P

25

65.9

(39 to 94)

53.5

(36 to 86)

-7.7

(-22 to 3.4)

T vs. R

0.92

R

50

63.45

(43.3 to 96.4)

78.1

(50.7 to 101)

7.7

(-7.3 to 18.5)

T + R vs. P

0.32

T

50

64.3

(47.8 to 80.4)

69.6

(51.7 to 86.8)

2.2

(-7.1 to 21.9)

Testosterone

P

25

0.26

(0.17 to 0.34)

0.28

(0.16 to 0.35)

0.02

(-0.08 to 0.07)

T vs. R

0.90

ng/mL

R

50

0.23

(0.16 to 0.32)

0.27

(0.18 to 0.36)

0.03

(-0.03 to 0.09)

T + R vs. P

0.10

T

50

0.23

(0.19 to 0.32)

0.27

(0.22 to 0.34)

0.02

(-0.02 to 0.09)

Estradiol ng/mL

P

25

120.3

(51.4 to 167.4)

104.35

(45.1 to 179.4)

-9.6

(-99.6 to 91)

T vs. R

0.45

R

50

94.35

(41.9 to 147.4)

124.7

(65.5 to 209)

27

(-62.9 to 159.08)

T + R vs. P

0.05

T

50

103.25

(61.98 to 165.5)

160.7

(70.86 to 306.4)

29.5

(-37.3 to 179.8)