Skip to main content

Table 4 The association of serum phthalates, parabens, and phenols with mammographic breast density (N = 264), Wisconsin Breast Density Study, 2008 to 2009

From: Circulating serum xenoestrogens and mammographic breast density

  Mean percentage density (95% confidence interval)a,b
Chemical Nondetected Below mediand Above mediand P trend c
  n = 225 n = 19 n = 18  
Mono-ethyl phthalate 13.1 (11.9, 14.3) 13.0 (9.1, 17.7) 18.2 (13.4, 23.7) 0.07
  n = 88 n = 88 n = 87  
Propyl paraben 12.7 (10.9, 14.8) 13.3 (11.4, 15.4) 13.9 (12.0, 16.1) 0.41
  n = 121 n = 72 n = 71  
Butyl paraben 14.4 (12.7, 16.3) 12.4 (10.4, 14.7) 12.4 (10.4, 14.7) 0.13
  n = 228 n = 19 n = 16  
Octylphenol 13.5 (12.3, 14.7) 11.3 (7.6, 15.6) 14.5 (9.9, 19.9) 0.93
  n = 155 n = 55 n = 54  
Nonylphenol 14.1 (12.6, 15.6) 12.1 (9.8, 14.7) 12.5 (10.1, 15.1) 0.21
  n = 193 n = 35 n = 34  
Bisphenol A 12.6 (11.4, 14.0) 13.7 (10.7, 17.1) 17.6 (14.1, 21.5) 0.01
  1. SE, standard error. aAdjusted for age, body mass index, parity, family history of breast cancer, vigorous physical activity, and smoking. bMean percentage density displayed is reverse transformed from model of square root density. cPtrend refers to the test for the ordinal variable representing nondetected, below median detected value, and above median detected value in a separate model. dRefers to the median of detected serum levels (that is, excluding nondetectable samples).