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Table 2 Association of mammographic measures with risk of breast cancer when using sister controls or unrelated controlsa

From: Mammographic density and breast cancer: a comparison of related and unrelated controls in the Breast Cancer Family Registry

   Sister controls (n = 228 pairs) Unrelated controls (n = 228 pairs)
  Inter-quintile rangeb Βeta (SE) P value Inter-quintile
OR (95% CI)c
Βeta (SE) P value Inter-quintile
OR (95% CI)
Percent density 10.0 - 48.1 0.2062 (0.0810) 0.01 2.19 (1.20, 4.00) 0.2538 (0.0648) <.0001 2.62 (1.62, 4.25)
Dense area 11.0 - 50.6 0.1499 (0.0607) 0.01 1.77 (1.12, 2.78) 0.2365 (0.0510) <.0001 2.46 (1.68, 3.59)
Non-dense area 45.1 - 136.7 -0.1364 (0.0598) 0.02 0.51 (0.28, 0.91) -0.0142 (0.0520) 0.78 0.93 (0.56, 1.55)
Total area 77.3 - 165.0 -0.0591 (0.0633) 0.35 0.79 (0.47, 1.31) 0.1483 (0.0596) 0.01 1.84 (1.14, 2.97)
  1. aAll coefficients are based on square root transformed mammogram measures; binter-quintile range from unrelated controls, on the untransformed mammographic measures; cinter-quintile odds ratio (95% confidence interval (CI)) is based on the inter-quintile range of square root transformed mammogram measures, adjusted for age at mammogram, parity, menopausal status, hormone usage (never, ever but not now, current using), and body mass index. OR, odds ratio; SD, standard error.