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Table 1 Hallmarks of cancer progression and roles played by the hemostatic system

From: Platelets, coagulation and fibrinolysis in breast cancer progression

Hallmarks of cancer progression Platelets Coagulation Fibrinolysis
Genetic instability Indirect evidence only [86] No No
Tumor-promoting inflammation No Yes [51] No
Sustained proliferative signaling Yes [14, 15, 25] Yes [51] Yes [76, 78]
Evasion of anti-growth signaling Yes [14] No No
Prevention of apoptosis Yes [14] Yes [51, 86] Yes [7678]
Replicative immortality No No No
Deregulated metabolism No No No
Immune system evasion Yes [12] No No
Angiogenesis Yes [15, 17, 23, 24] Yes [51, 68, 70, 72] Yes [79]
Tissue invasion and metastasis Yes [6, 14, 15, 18, 25, 32] Yes [51, 70] Yes [76, 77]