Table 1 Hallmarks of cancer progression and roles played by the hemostatic system
From: Platelets, coagulation and fibrinolysis in breast cancer progression
| Hallmarks of cancer progression | Platelets | Coagulation | Fibrinolysis |
|---|---|---|---|
| Genetic instability | Indirect evidence only [86] | No | No |
| Tumor-promoting inflammation | No | Yes [51] | No |
| Sustained proliferative signaling | Yes [14, 15, 25] | Yes [51] | Yes [76, 78] |
| Evasion of anti-growth signaling | Yes [14] | No | No |
| Prevention of apoptosis | Yes [14] | Yes [51, 86] | Yes [76–78] |
| Replicative immortality | No | No | No |
| Deregulated metabolism | No | No | No |
| Immune system evasion | Yes [12] | No | No |
| Angiogenesis | Yes [15, 17, 23, 24] | Yes [51, 68, 70, 72] | Yes [79] |
| Tissue invasion and metastasis | Yes [6, 14, 15, 18, 25, 32] | Yes [51, 70] | Yes [76, 77] |
