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Table 2 Multivariate regression of baseline characteristics and the first principal component with adjusted percent mammographic density

From: High mammographic density in women of Ashkenazi Jewish descent

  Univariate analyses Multivariate analysis
  Odds ratio (95% confidence interval) Pvalue Odds ratio (95% confidence interval) Pvalue
First principal component 2.00 (1.26 to 3.17) 0.003 2.22 (1.36 to 3.65) 0.002
Body mass index     
   First quartile (<21 kg/m2) Reference   Reference  
   Second quartile (21 to 23 kg/m2) 0.41 (0.28 to 0.59) <0.001 0.38 (0.26 to 0.57) <0.001
   Third quartile (23 to 26 kg/m2) 0.33 (0.23 to 0.49) <0.001 0.31 (0.21 to 0.46) <0.001
   Fourth quartile (>26 kg/m2) 0.44 (0.30 to 0.63) <0.001 0.48 (0.32 to 0.71) <0.001
Age at first live birth     
   <30 years Reference   Reference  
   ≥30 years or nulliparous 1.27 (0.93 to 1.72) 0.1 1.13 (0.80 to 1.59) 0.5
Menopausal status     
   Premenopausal Reference   Reference  
   Postmenopausal 0.67 (0.50 to 0.90) 0.009 0.67 (0.49 to 0.92) 0.01
   Postmenopausal on hormone therapy 0.72 (0.49 to 1.06) 0.1 0.74 (0.49 to 1.10) 0.1
  1. Odds ratios are for likelihood of having high adjusted percent mammographic density compared with low adjusted percent mammographic density. Univariate and multivariate P values are calculated using chi-squared tests.