A | Fraction of large colonies | Fraction of double-positive colonies | ||||
---|---|---|---|---|---|---|
Virgins | Parous | Virgins | Parous | |||
Myoepithelial^{a} | 32.7 ± 7.4%^{a} | 9.6 ± 2.3%^{a} | 0% | 0% | ||
Basal stem/progenitor^{a} | 66.2 ± 7.2%^{a} | 9.3 ± 4.5%^{a} | 26.1 ± 2.7% | 0% | ||
Luminal Sca1^{-b} | 36.3 ± 5.6%^{b} | 31.3 ± 2.6%^{b} | 84.0 ± 3.4% | 57.1 ± 2.9% | ||
Luminal Sca1^{+a} | 73.3 ± 1.8%^{a} | 71.8 ± 4.1%^{a} | 64.1 ± 3.6% | 59.8 ± 2.7% | ||
B
Number of basal stem/progenitor cells injected per cleared fat pad | Number of positive outgrowths ^{c, d, e} | |||||
Age-matched virgin control donors | Parous donors | |||||
1,000 | ^{c}8/9 | ^{d}8/9 | ^{e}8/9 | ^{c}3/9 | ^{d}3/9 | ^{e}4/9 |
500 | ^{c}8/11 | ^{d}8/11 | ^{e}8/11 | ^{c}2/11 | ^{d}2/11 | ^{e}6/11 |
250 | ^{c}2/6 | ^{d}2/6 | ^{e}2/6 | ^{c}0/6 | ^{d}1/6 | ^{e}1/6 |
100 | ^{c}0/6 | ^{d}1/6 | ^{e}1/6 | ^{c}0/6 | ^{d}0/6 | ^{e}2/6 |
50 | ^{c}0/7 | ^{d}0/7 | ^{e}0/7 | ^{c}1/7 | ^{d}1/7 | ^{e}1/7 |
Repopulating frequency (95% confidence interval) | ^{c}1/507 (1/827 - 1/311) | ^{c}1/2468 (1/5,522 to 1/1104) | ||||
^{d}1/472 (1/767 - 1/291) | ^{d}1/2095 (1/4,441 to 1/988) | |||||
^{e}1/472 (1/767 - 1/291) | ^{e}1/907 (1/1582 - 1/520) | |||||
P value | ^{c}P = 0.0004; ^{d}P = 0.0004; ^{e}P = 0.076. |