Table 1 microRNAs as potential targets for breast cancer therapy
From: Delivery of gene silencing agents for breast cancer therapy
microRNA | Selected target gene(s) | Function | References |
|---|---|---|---|
let-7 | KRAS, MYC | Tumor growth inhibition | |
miR-17/20 | CCND1, IL-8 | Regulation of tumor microenvironment | [48] |
miR-21 | PTEN/AKT pathway | Tumor progression and metastasis | [9] |
miR-103/107 | Dicer | Global microRNA downregulation | [10] |
miR-200 family | ZEB1, SIP1 | Epithelial-mesenchymal transition | [49] |
miR-205 | HER3, E2F, ZEB1 | Regulation of HER3 expression | [11] |
miR-206 | ERα | Suppression of ERα expression | [50] |
miR-221/222 | ERα | Tamoxifen resistance by suppression of ERα expression | [51] |
miR-708 | NNAT | Inhibition of tumor metastasis | [52] |