Figure 3
From: Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling
Expression of mast cells (MCs) tryptase staining on lungs. (A) Significant increase in MCs tryptase count in the lungs of arthritic SKG mice challenged with 4T1 cells versus nonarthritic Balb/C mice injected with 4T1 cells (***P < 0.001) and in arthritic PyV MT mice induced with CII versus nonarthritic PyV MT mice (***P < 0.001). Significant increase in MCs tryptase also is observed in the lungs of arthritic SKG mice with no tumor versus Balb/C mice with breast cancer (BC; *P < 0.05). Similarly, we see the same trend in arthritic C57BL/6 mice induced with CII versus spontaneous BC model of PyV MT mice with no arthritis (*P < 0.05). Representative images of tryptase staining in (B, C) lungs taken at 600× magnification (six mice per experimental group and 10 fields per section). Brown staining represents MCs tryptase expression.