Figure 10

Significant reduction in number of mast cells (MCs) (tryptase staining) in the tumor, lungs, and bones of mice treated with anti-SCF or anti-ckit antibody. (A through C) Significant reduction in number of MCs in (A) tumors (**P < 0.01; ***P < 0.001), (B) lungs (*P < 0.05; **P < 0.01), and (C) bones (*P < 0.05; **P < 0.01) of treated mice. (D through F) Representative images of MCs tryptase in (D) tumors (400×), (E) lungs (600×), and (F) bones (400× magnification) (six mice per experimental group and 10 fields per section per organ). Brown staining represents MCs tryptase expression.