|  | RFS | OS | ||||
---|---|---|---|---|---|---|---|
 |  | HR | 95% CI | TxM (HR) | HR | 95% CI | TxM (HR) |
TIMP-1 | Negative (n = 167; 58%) | 0.642 | 0.377 to 1.091 | 1.311 | 0.784 | 0.447 to 1.376 | 1.667 |
 | Positive (n = 121; 42%) | 0.478 | 0.247 to 0.927 | (0.562 to 3.056) | 0.461 | 0.213 to 1.002 | (0.641 to 4.339) |
2T Profile | Responsive (n = 183; 66.8%) | 0.613 | 0.365 to 1.029 | 1.022 | 0.450 | 0.188 to 1.080 | 1.579 |
 | Non-responsive (n = 91; 33.2%) | 0.582 | 0.277 to 1.221 | (0.415 to 2.520) | 0.739 | 0.428 to 1.277 | (0.565 to 4.411) |
HT Profile | Responsive (n = 181; 66.1%) | 0.658 | 0.400 to 1.082 | 0.902 | 0.783 | 0.464 to 1.320 | 0.577 |
 | Non-responsive (n = 93; 33.9%) | 0.531 | 0.235 to 1.200 | (0.347 to 2.346) | 0.384 | 0.141 to 1.046 | (0.186 to 1.788) |