Figure 4

HIF-1α and aromatase expression in ASCs from tumor-bearing breast tissue compared to cancer-free using immunohistochemistry. (A) Percentage of HIF-1α positive ASCs from tumor-bearing breast tissue was significantly increased compared to tissue from cancer-free women. (B) Double-positive and single-positive ASCs for HIF-1α and aromatase were shown to be significantly increased in tumor-bearing compared to cancer-free tissues. Double negative ASCs for HIF-1α and aromatase were significantly reduced in tumor-bearing compared to cancer-free tissues. n = 10 for tumor-bearing breast tissue; n = 10/cancer-free breast tissue.