Figure 2From: HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stromaRole of HIF-1α in aromatase regulation. (A) ChIP demonstrated that PGE2 and DMOG significantly stimulate the endogenous binding of HIF-1α to aromatase PII. Treatment of ASCs with PGE2 or DMOG caused a significant increase in aromatase transcript expression (B) and activity (C). (D) HIF-1α overexpression in MCF-7 cells significantly increased aromatase activity in the presence of PGE2. vc = vehicle control, n = 3, repeated twice.Back to article page