Table 2 Over-represented functional categories within genes up- and/or down-regulated after celecoxib treatment using DAVID.
GO-ID | Term | Count | Fold enrichment | P-valuea |
|---|---|---|---|---|
Up-regulated | ||||
0030198 | Extracellular matrix organisation | 28 | 4.657 | 6.35E-08 |
0009611 | Response to wounding | 70 | 2.337 | 1.32E-07 |
0007155 | Cell adhesion | 83 | 2.108 | 3.24E-07 |
0022610 | Biological adhesion | 83 | 2.105 | 3.46E-07 |
0001944 | Vasculature development | 43 | 2.951 | 1.20E-06 |
0001568 | Blood vessel development | 42 | 2.953 | 1.96E-06 |
0043062 | Extracellular structure organisation | 33 | 3.502 | 2.35E-06 |
0051270 | Regulation of cell motion | 34 | 3.047 | 4.89E-05 |
0001501 | Skeletal system development | 46 | 2.510 | 5.23E-05 |
0030334 | Regulation of cell migration | 31 | 3.173 | 9.15E-05 |
0040012 | Regulation of locomotion | 33 | 2.973 | 1.51E-04 |
0042127 | Regulation of cell proliferation | 83 | 1.834 | 2.27E-04 |
0042060 | Wound healing | 32 | 2.944 | 3.14E-04 |
0007160 | Cell-matrix adhesion | 20 | 3.931 | 1.42E-03 |
0048514 | Blood vessel morphogenesis | 33 | 2.692 | 1.56E-03 |
0031589 | Cell-substrate adhesion | 21 | 3.745 | 1.57E-03 |
0006928 | Cell motion | 53 | 1.984 | 7.97E-03 |
0001525 | Angiogenesis | 25 | 2.922 | 1.15E-02 |
0009612 | Response to mechanical stimulus | 14 | 4.324 | 3.91E-02 |
Down-regulated | ||||
0006259 | DNA metabolic process | 52 | 3.018 | 5.10E-09 |
0007049 | Cell cycle | 64 | 2.411 | 1.85E-07 |
0006260 | DNA replication | 28 | 4.387 | 3.98E-07 |
0022402 | Cell cycle process | 50 | 2.569 | 4.12E-06 |
0000278 | Mitotic cell cycle | 37 | 2.898 | 3.70E-05 |
0000279 | M phase | 32 | 2.832 | 6.92E-04 |
0051276 | Chromosome organisation | 40 | 2.461 | 7.18E-04 |
0006974 | Response to DNA damage stimulus | 34 | 2.656 | 1.20E-03 |
0000087 | M phase of mitotic cell cycle | 25 | 3.229 | 1.76E-03 |
0022613 | Ribonucleoprotein complex biogenesis | 22 | 3.544 | 2.07E-03 |
0000280 | Nuclear division | 24 | 3.156 | 4.53E-03 |
0007067 | Mitosis | 24 | 3.156 | 4.53E-03 |
0022403 | Cell cycle phase | 35 | 2.454 | 4.81E-03 |
0042254 | Ribosome biogenesis | 17 | 4.062 | 8.27E-03 |
0048285 | Organelle fission | 24 | 3.031 | 9.01E-03 |
0006281 | DNA repair | 27 | 2.785 | 9.53E-03 |
0006396 | RNA processing | 41 | 2.185 | 1.01E-02 |
0031396 | Regulation of protein ubiquitination | 15 | 4.434 | 1.30E-02 |
0031397 | Negative regulation of protein ubiquitination | 13 | 5.177 | 1.31E-02 |
0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 12 | 5.461 | 2.01E-02 |
0016071 | mRNA metabolic process | 31 | 2.428 | 2.52E-02 |
0034470 | ncRNA processing | 20 | 3.133 | 4.28E-02 |
0051439 | Regulation of ubiquitin-protein ligase activity during mitotic cell cycle | 12 | 4.986 | 4.85E-02 |