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Table 3 Relative risks (RR) of breast cancer death associated with each risk classifier among ER-positive patients, stratified by treatment with tamoxifen.

From: HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease

  Cases Controls     
Risk classifier n % n % RR1 95% CI RR2 95% CI
Tamoxifen treated (49 cases and 112 controls)
   HOXB13:IL17BR         
Low risk 19 39% 58 52% 1.0 ref 1.0 ref
High risk 30 61% 54 48% 1.9 0.9 - 3.7 1.5 0.7 - 3.2
   MGI         
Low risk 12 24% 55 49% 1.0 ref 1.0 ref
High risk 37 76% 57 51% 2.9 1.3 - 6.2 2.1 0.8 - 5.5
   MGI+HOXB13:IL17BR         
Low risk 12 24% 55 49% 1.0 ref 1.0 ref
Intermediate risk 14 29% 31 28% 1.8 0.7 - 4.8 1.3 0.4 - 4.2
High risk 23 47% 26 23% 3.5 1.5 - 8.1 2.7 0.9 - 7.5
   BCI         
Low risk 13 27% 61 54% 1.0 ref 1.0 ref
Intermediate risk 15 31% 29 26% 2.2 0.9 - 5.6 2.1 0.8 - 6.0
High risk 21 43% 22 20% 4.2 1.7 - 10.3 3.3 1.1 - 10.3
Tamoxifen untreated (90 cases and 174 controls)
   HOXB13:IL17BR         
Low risk 41 46% 101 58% 1.0 ref 1.0 ref
High risk 49 54% 73 42% 1.6 1.0 - 2.7 1.3 0.8 - 2.3
   MGI         
Low risk 32 36% 99 57% 1.0 ref 1.0 ref
High risk 58 64% 75 43% 2.6 1.5 - 4.8 1.7 0.8 - 3.4
   MGI+HOXB13:IL17BR         
Low risk 32 36% 99 57% 1.0 ref 1.0 ref
Intermediate risk 27 30% 39 22% 2.5 1.3 - 4.8 1.7 0.8 - 3.6
High risk 31 34% 36 21% 2.9 1.4 - 5.8 1.6 0.7 - 3.8
   BCI         
Low risk 30 33% 108 62% 1.0 ref 1.0 ref
Intermediate risk 26 29% 28 16% 3.9 1.9 - 8.0 3.2 1.5 - 6.8
High risk 34 38% 38 22% 3.6 1.8 - 7.4 2.0 0.8 - 4.9
  1. 1Univariate conditional logistic regression models include HOXB13:IL17BR, MGI, MGI+HOXB13:IL17BR or BCI; 2multivariable conditional logistic regression models include HOXB13:IL17BR, MGI, MGI+HOXB13:IL17BR or BCI plus tumor size (≤2.0,>2.0) and grade (well, intermediate, poor).