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Table 1 Selected characteristics of the study population: 191 cases, 417 controls.

From: HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease

 

Cases

Controls

Characteristic

n(%)

n(%)

Matched variables

   Age at diagnosis (years)

<40

15(8%)

20(5%)

40-49

33(17%)

94(22%)

50-59

59(31%)

113(27%)

60-74

84(44%)

190(46%)

   Race/ethnicity

White, non-Hispanic

146(76%)

326(78%)

White, Hispanic

7(4%)

11(3%)

Black

19(10%)

42(10%)

Asian

19(10%)

38(9%)

   Surgery year

1985-1989

127(66%)

278(67%)

1990-1994

64(34%)

139(33%)

   Adjuvant tamoxifen

No

134(70%)

281(67%)

Yes

57(30%)

136(33%)

Unmatched variables

   Tumor size (cm)

≤ 1.0

40(21%)

128(31%)

1.1-2.0

84(44%)

187(45%)

2.1-4.0

63(33%)

96(23%)

>4.0

4(2%)

6(1%)

   Tumor grade (differentiation)1

Well

21(11%)

123(29%)

Moderate

79(41%)

182(44%)

Poor

91(48%)

112(27%)

   ER status from RT-PCR2

Positive

145(76%)

370(89%)

Negative

46(24%)

47(11%)

   PR status from RT-PCR2

Positive

117(61%)

324(78%)

Negative

74(39%)

93(22%)

   HER2 status from RT-PCR2

Positive

33(17%)

41(10%)

Negative

158(83%)

376(90%)

   HOXB13:IL17BR

  

Low risk

71(37%)

222(53%)

High risk

120(63%)

195(47%)

   MGI

  

Low risk

51(27%)

197(47%)

High risk

140(73%)

220(53%)

   MGI+HOXB13:IL17BR

  

Low risk

51(27%)

197(47%)

Intermediate risk

50(26%)

108(26%)

High risk

90(47%)

112(27%)

   BCI

  

Low risk

55(29%)

222(53%)

Intermediate risk

54(28%)

85(20%)

High risk

82(43%)

110(26%)

  1. 1Modified Bloom-Richardson grading criteria; 2performed by Genomic Health, Inc. (ER cut points ≤ 6.5 and >6.5 units; PR cut points <5.5 and ≥5.5 units; HER2 cut points <11.5 and ≥11.5 units).