Figure 4
From: Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer
ER stress increases PrP levels in MDA-MB-231, HS578T and HCC1500 cell lines. Western blot of (A) PrP in protein extracts of MCF-7, MDA-MB-231, HS578T and HCC1500 cell lines, (B) PrP and BiP in protein extracts from HCC1500 cells treated with BFA, TM or Thps, (C) PrP and BiP in protein extracts from MCF-7, MDA-MB-231 and HS578T cell lines treated with 4-PBA or vehicle, (D) PrP and BiP in protein extracts of MDA-MB-231 and HS578T cell lines treated with BFA, TM and Thps. β-actin was probed as a loading control.