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Figure 1 | Breast Cancer Research

Figure 1

From: Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling

Figure 1

Oestrogenic effects on cancer stem cells. Cells were cultured for 48 hours in a monolayer in the presence of 1 nM 17β-estradiol or vehicle control and CSC assays were performed in ER positive cells (primary, MCF7, T47D and BT474) and ER negative cells (231). (A) Mammosphere formation, (B) holoclone formation and (C) expression of ESA+ CD44+ CD24low were measured. Means plotted ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001.

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